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atn-1 Alpha-actinin, sarcomeric [ Caenorhabditis elegans ]

Gene ID: 179709, updated on 2-Nov-2024

Summary

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Official Symbol
atn-1
Official Full Name
Alpha-actinin, sarcomeric
Primary source
WormBase:WBGene00000228
Locus tag
CELE_W04D2.1
See related
AllianceGenome:WB:WBGene00000228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and muscle cell development. Located in dense body; striated muscle dense body; and striated muscle thin filament. Is expressed in several structures, including body wall; body wall musculature; non-striated muscle; pharynx; and tail. Human ortholog(s) of this gene implicated in congenital myopathy 8; focal segmental glomerulosclerosis (multiple); intrinsic cardiomyopathy (multiple); and platelet-type bleeding disorder 15. Orthologous to several human genes including ACTN2 (actinin alpha 2) and ACTN3 (actinin alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atn-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (12478411..12484449)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene Innexin;Innexin-11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Facioscapulohumeral muscular dystrophy region gene-1 (FRG-1) is an actin-bundling protein associated with muscle-attachment sites. Liu Q, et al. J Cell Sci, 2010 Apr 1. PMID 20215405, Free PMC Article
  2. Cloning, sequencing, and mapping of an alpha-actinin gene from the nematode Caenorhabditis elegans. Barstead RJ, et al. Cell Motil Cytoskeleton, 1991. PMID 1756579
  3. Muscle organization in Caenorhabditis elegans: localization of proteins implicated in thin filament attachment and I-band organization. Francis GR, et al. J Cell Biol, 1985 Oct. PMID 2413045, Free PMC Article
  4. HSP25, a small heat shock protein associated with dense bodies and M-lines of body wall muscle in Caenorhabditis elegans. Ding L, et al. J Biol Chem, 2000 Mar 31. PMID 10734099
  5. Fascin- and α-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting. Winkelman JD, et al. Curr Biol, 2016 Oct 24. PMID 27666967, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fascin and alpha-actinin intrinsically segregate to discrete bundled domains that are specifically recognized by other actin-binding proteins.
    Title: Fascin- and α-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dense body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Alpha-actinin, sarcomeric
NP_001256423.1
  • Confirmed by transcript evidence
NP_001256424.1
  • Confirmed by transcript evidence
NP_506127.1
  • Confirmed by transcript evidence
NP_506128.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12478411..12484449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073727.5 → NP_506128.1  Alpha-actinin, sarcomeric [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506128.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XVU8
    Conserved Domains (6) summary
    cd00014
    Location:151 → 254
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:756 → 822
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:400 → 628
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:279 → 388
    Spectrin; Spectrin repeat
    pfam08726
    Location:827 → 893
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cl02488
    Location:641 → 739
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. NM_073726.6 → NP_506127.1  Alpha-actinin, sarcomeric [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506127.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23158
    Conserved Domains (6) summary
    cd00014
    Location:151 → 254
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:782 → 848
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:426 → 654
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:305 → 414
    Spectrin; Spectrin repeat
    pfam08726
    Location:853 → 919
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cl02488
    Location:667 → 765
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  3. NM_001269494.3 → NP_001256423.1  Alpha-actinin, sarcomeric [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256423.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2C9
    Conserved Domains (7) summary
    smart00033
    Location:3 → 68
    CH; Calponin homology domain
    cd00014
    Location:80 → 183
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:711 → 777
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:355 → 583
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:234 → 343
    Spectrin; Spectrin repeat
    pfam08726
    Location:782 → 848
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cl02488
    Location:596 → 694
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  4. NM_001269495.3 → NP_001256424.1  Alpha-actinin, sarcomeric [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256424.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2C8
    Conserved Domains (7) summary
    smart00033
    Location:3 → 68
    CH; Calponin homology domain
    cd00014
    Location:80 → 183
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:685 → 751
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:329 → 557
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:208 → 317
    Spectrin; Spectrin repeat
    pfam08726
    Location:756 → 822
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cl02488
    Location:570 → 668
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Nucleotide Protein
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