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vav-1 Protein vav;Protein vav-1 [ Caenorhabditis elegans ]

Gene ID: 181153, updated on 2-Nov-2024

Summary

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Official Symbol
vav-1
Official Full Name
Protein vav;Protein vav-1
Primary source
WormBase:WBGene00006887
Locus tag
CELE_C35B8.2
See related
AllianceGenome:WB:WBGene00006887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of nematode male tail tip morphogenesis; and regulation of vulval development. Predicted to be active in cytoplasm. Is expressed in several structures, including gonad; intestine; nervous system; pharynx; and tail hypodermis. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1); VAV2 (vav guanine nucleotide exchange factor 2); and VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vav-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Sequence:
Chromosome: X; NC_003284.9 (9216866..9232137, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Zn(2)-C6 fungal-type domain-containing protein Neighboring gene Syndecan Neighboring gene T-cell activation inhibitor, mitochondrial Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Ligand-gated ion channel 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans. Fry AL, et al. Genetics, 2016 Mar. PMID 26801183, Free PMC Article
  2. VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans. Fry AL, et al. Nat Commun, 2014 Nov 21. PMID 25412913, Free PMC Article
  3. LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Yoo AS, et al. Science, 2005 Nov 25. PMID 16239437, Free PMC Article
  4. Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans. Spooner PM, et al. PLoS One, 2012. PMID 22768340, Free PMC Article
  5. DEC-7/SUSD2, a sushi domain-containing protein, regulates an ultradian behavior mediated by intestinal epithelial Ca(2+) oscillations in Caenorhabditis elegans. Laboy JT, et al. Am J Physiol Cell Physiol, 2023 May 1. PMID 37067458, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We show that Rho/Rac-family GTPases and the signaling molecule inositol triphosphate (IP(3)) act downstream of VAV-1 signaling and that the VAV-1 pathway modulates rhythmic behaviors by regulating the concentration of intracellular Ca(2+).(VAV-1)
    Title: The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans.
  2. VAV-1 in the ALA interneuron also serves a critical function to suppress locomotion and feeding behavior during sleep-like quiescence
    Title: A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans.
  3. The data describe a novel neuromodulatory role for VAV-1-dependent signaling in the regulation of motor circuit activity and locomotion.
    Title: VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans.
  4. results suggest that lin-12, mir-61, and vav-1 form a feedback loop that helps maximize lin-12 activity in spatial patterning 2 of vulval precursor cells
    Title: LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein vav;Protein vav-1
NP_001041222.1
  • Confirmed by transcript evidence
NP_001359918.1
  • Confirmed by transcript evidence
NP_001360680.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9216866..9232137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373413.3 → NP_001360680.1  Protein vav [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ILE7
    Conserved Domains (7) summary
    cd09940
    Location:821 → 921
    SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
    smart00326
    Location:923 → 983
    SH3; Src homology 3 domains
    cd00014
    Location:34 → 145
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00029
    Location:612 → 653
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:237 → 431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17036
    Location:689 → 742
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:449 → 598
    PH-like; Pleckstrin homology-like domain

  2. NM_001047757.3 → NP_001041222.1  Protein vav-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041222.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q45FX5
    Conserved Domains (7) summary
    cd09940
    Location:793 → 893
    SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
    smart00326
    Location:895 → 955
    SH3; Src homology 3 domains
    cd00014
    Location:6 → 117
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00029
    Location:584 → 625
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:209 → 403
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam00169
    Location:447 → 561
    PH; PH domain
    cl17171
    Location:421 → 570
    PH-like; Pleckstrin homology-like domain

  3. NM_001373412.3 → NP_001359918.1  Protein vav-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18479, Q45FX5
    Conserved Domains (7) summary
    cd09940
    Location:825 → 925
    SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
    smart00326
    Location:927 → 987
    SH3; Src homology 3 domains
    cd00014
    Location:38 → 149
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00029
    Location:616 → 657
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:241 → 435
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:453 → 602
    PH_Vav; Vav pleckstrin homology (PH) domain
    cl17036
    Location:693 → 746
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q45FX5.1

Gene LinkOut

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