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fln-2 Calponin-homology (CH) domain-containing protein;Filamin-A;ZM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181168, updated on 2-Nov-2024

Summary

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Official Symbol
fln-2
Official Full Name
Calponin-homology (CH) domain-containing protein;Filamin-A;ZM domain-containing protein
Primary source
WormBase:WBGene00016006
Locus tag
CELE_C23F12.1
See related
AllianceGenome:WB:WBGene00016006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in organelle. Is expressed in several structures, including anal depressor muscle; distal tip cell; excretory canal; hypodermis; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fln-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
53
Sequence:
Chromosome: X; NC_003284.9 (9397701..9427247)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Zinc finger, CCHC-type Neighboring gene Transposase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene putative 3-hydroxyacyl-CoA dehydrogenase B0272.3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2. DeMaso CR, et al. PLoS One, 2011. PMID 21799850, Free PMC Article
  2. FLN-2 functions in parallel to linker of nucleoskeleton and cytoskeleton complexes and CDC-42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans. Ma L, et al. Genetics, 2024 Jul 8. PMID 38797871,
  3. Intracellular Ca(2+) dynamics in the ALA neuron reflect sleep pressure and regulate sleep in Caenorhabditis elegans. Miyazaki S, et al. iScience, 2022 Jun 17. PMID 35707721, Free PMC Article
  4. A fln-2 mutation affects lethal pathology and lifespan in C. elegans. Zhao Y, et al. Nat Commun, 2019 Nov 8. PMID 31704915, Free PMC Article
  5. Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton. Shi L, et al. J Cell Biol, 2022 Jul 4. PMID 35575797, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLN-2 functions in parallel to linker of nucleoskeleton and cytoskeleton complexes and CDC-42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans.
    Title: FLN-2 functions in parallel to linker of nucleoskeleton and cytoskeleton complexes and CDC-42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans.
  2. Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton.
    Title: Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton.
  3. gene and protein structures of the C. elegans filamin orthologs fln-1 and fln-2
    Title: Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2.
  4. A nonsense mutation in fln-2 in the male stock reduces early mortality caused by pharyngeal infection. fln-2 variation confounds effects on lifespan of sir-2.1, daf-2, daf-12, and eat-2.
    Title: A fln-2 mutation affects lethal pathology and lifespan in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Calponin-homology (CH) domain-containing protein;Filamin-A;ZM domain-containing protein
NP_001257074.2
  • Confirmed by transcript evidence
NP_001257075.2
  • Confirmed by transcript evidence
NP_001300321.1
  • Confirmed by transcript evidence
NP_001300323.1
  • Confirmed by transcript evidence
NP_001300324.1
  • Confirmed by transcript evidence
NP_001300325.1
  • Confirmed by transcript evidence
NP_001300326.1
  • Confirmed by transcript evidence
NP_001300327.1
  • Confirmed by transcript evidence
NP_001300328.1
  • Confirmed by transcript evidence
NP_001300329.1
  • Confirmed by transcript evidence
NP_001300330.1
  • Confirmed by transcript evidence
NP_001300331.1
  • Confirmed by transcript evidence
NP_001300332.1
  • Confirmed by transcript evidence
NP_001359882.1
  • Confirmed by transcript evidence
NP_001360405.1
  • Confirmed by transcript evidence
NP_001360663.1
  • Confirmed by transcript evidence
NP_001360664.1
  • Confirmed by transcript evidence
NP_001360665.1
  • Confirmed by transcript evidence
NP_001360666.1
  • Confirmed by transcript evidence
NP_001360667.1
  • Confirmed by transcript evidence
NP_001360668.1
  • Confirmed by transcript evidence
NP_001368576.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9397701..9427247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373422.1 → NP_001359882.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0VWL6
    Conserved Domains (6) summary
    PTZ00121
    Location:1506 → 1928
    PTZ00121; MAEBL; Provisional
    smart00557
    Location:3445 → 3539
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:11 → 242
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:2933 → 3019
    Filamin; Filamin/ABP280 repeat
    cl00030
    Location:235 → 327
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl27659
    Location:2589 → 2652
    Filamin; Filamin/ABP280 repeat

  2. NM_001373425.2 → NP_001360405.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AT74
    Conserved Domains (5) summary
    PTZ00121
    Location:1475 → 1897
    PTZ00121; MAEBL; Provisional
    smart00557
    Location:3060 → 3154
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:11 → 242
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:2548 → 2634
    Filamin; Filamin/ABP280 repeat
    cl00030
    Location:235 → 327
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  3. NM_001373423.2 → NP_001360663.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IK09
    Conserved Domains (5) summary
    PTZ00121
    Location:1506 → 1928
    PTZ00121; MAEBL; Provisional
    smart00557
    Location:3091 → 3185
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:11 → 242
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:2579 → 2665
    Filamin; Filamin/ABP280 repeat
    cl00030
    Location:235 → 327
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  4. NM_001373424.2 → NP_001360664.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IKI4
    Conserved Domains (6) summary
    PTZ00121
    Location:1475 → 1897
    PTZ00121; MAEBL; Provisional
    smart00557
    Location:3414 → 3508
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:11 → 242
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:2902 → 2988
    Filamin; Filamin/ABP280 repeat
    cl00030
    Location:235 → 327
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl27659
    Location:2558 → 2621
    Filamin; Filamin/ABP280 repeat

  5. NM_001373426.2 → NP_001360665.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0INA2
    Conserved Domains (6) summary
    PTZ00121
    Location:1478 → 1900
    PTZ00121; MAEBL; Provisional
    smart00557
    Location:3417 → 3511
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:11 → 242
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:2905 → 2991
    Filamin; Filamin/ABP280 repeat
    cl00030
    Location:235 → 327
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl27659
    Location:762 → 826
    Filamin; Filamin/ABP280 repeat

  6. NM_001373427.2 → NP_001360666.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IN32
    Conserved Domains (6) summary
    PTZ00121
    Location:1478 → 1900
    PTZ00121; MAEBL; Provisional
    smart00557
    Location:3063 → 3157
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:11 → 242
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:2551 → 2637
    Filamin; Filamin/ABP280 repeat
    cl00030
    Location:235 → 327
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl27659
    Location:762 → 826
    Filamin; Filamin/ABP280 repeat

  7. NM_001373428.2 → NP_001360667.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V6M3C1
    Conserved Domains (6) summary
    PTZ00121
    Location:1447 → 1869
    PTZ00121; MAEBL; Provisional
    smart00557
    Location:3386 → 3480
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:11 → 242
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:2874 → 2960
    Filamin; Filamin/ABP280 repeat
    cl00030
    Location:235 → 327
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl27659
    Location:762 → 826
    Filamin; Filamin/ABP280 repeat

  8. NM_001373429.2 → NP_001360668.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IK63
    Conserved Domains (6) summary
    PTZ00121
    Location:1447 → 1869
    PTZ00121; MAEBL; Provisional
    smart00557
    Location:3032 → 3126
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:11 → 242
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:2520 → 2606
    Filamin; Filamin/ABP280 repeat
    cl00030
    Location:235 → 327
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl27659
    Location:762 → 826
    Filamin; Filamin/ABP280 repeat

  9. NM_001381052.2 → NP_001368576.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASM8
    Conserved Domains (3) summary
    PTZ00121
    Location:138 → 560
    PTZ00121; MAEBL; Provisional
    smart00557
    Location:1723 → 1817
    IG_FLMN; Filamin-type immunoglobulin domains
    cl27659
    Location:1231 → 1304
    Filamin; Filamin/ABP280 repeat

  10. NM_001313394.3 → NP_001300323.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AW96
    Conserved Domains (3) summary
    smart00557
    Location:2873 → 2967
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2870 → 2960
    Filamin; Filamin/ABP280 repeat
    pfam15223
    Location:689 → 879
    DUF4584; Domain of unknown function (DUF4584)

  11. NM_001313395.3 → NP_001300324.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AYH6
    Conserved Domains (2) summary
    smart00557
    Location:2488 → 2582
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2485 → 2575
    Filamin; Filamin/ABP280 repeat

  12. NM_001313396.3 → NP_001300325.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AT80
    Conserved Domains (3) summary
    smart00557
    Location:2698 → 2792
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2695 → 2785
    Filamin; Filamin/ABP280 repeat
    pfam15223
    Location:514 → 704
    DUF4584; Domain of unknown function (DUF4584)

  13. NM_001313397.3 → NP_001300326.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVH8
    Conserved Domains (2) summary
    smart00557
    Location:2313 → 2407
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2310 → 2400
    Filamin; Filamin/ABP280 repeat

  14. NM_001270146.3 → NP_001257075.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0VWL8
    Conserved Domains (2) summary
    smart00557
    Location:2225 → 2319
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2222 → 2312
    Filamin; Filamin/ABP280 repeat

  15. NM_001270145.4 → NP_001257074.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0VWL7
    Conserved Domains (3) summary
    smart00557
    Location:2610 → 2704
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2607 → 2697
    Filamin; Filamin/ABP280 repeat
    pfam15223
    Location:426 → 616
    DUF4584; Domain of unknown function (DUF4584)

  16. NM_001313398.3 → NP_001300327.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASN4
    Conserved Domains (3) summary
    smart00557
    Location:2554 → 2648
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2551 → 2641
    Filamin; Filamin/ABP280 repeat
    pfam15223
    Location:370 → 560
    DUF4584; Domain of unknown function (DUF4584)

  17. NM_001313399.3 → NP_001300328.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWA2
    Conserved Domains (2) summary
    smart00557
    Location:2169 → 2263
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2166 → 2256
    Filamin; Filamin/ABP280 repeat

  18. NM_001313400.3 → NP_001300329.1  Filamin-A [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AYI1
    Conserved Domains (3) summary
    smart00557
    Location:2490 → 2584
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2487 → 2577
    Filamin; Filamin/ABP280 repeat
    pfam15223
    Location:306 → 496
    DUF4584; Domain of unknown function (DUF4584)

  19. NM_001313401.3 → NP_001300330.1  Filamin-A [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AT86
    Conserved Domains (2) summary
    smart00557
    Location:2105 → 2199
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2102 → 2192
    Filamin; Filamin/ABP280 repeat

  20. NM_001313402.3 → NP_001300331.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVI4
    Conserved Domains (3) summary
    smart00557
    Location:2249 → 2343
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2246 → 2336
    Filamin; Filamin/ABP280 repeat
    pfam15223
    Location:65 → 255
    DUF4584; Domain of unknown function (DUF4584)

  21. NM_001313403.3 → NP_001300332.1  ZM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASN9
    Conserved Domains (2) summary
    smart00557
    Location:1864 → 1958
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:1861 → 1951
    Filamin; Filamin/ABP280 repeat

  22. NM_001313392.3 → NP_001300321.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVH5
    Conserved Domains (2) summary
    smart00557
    Location:2077 → 2171
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:2074 → 2164
    Filamin; Filamin/ABP280 repeat

RNA

  1. NR_132548.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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