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pgp-5 P-GlycoProtein related [ Caenorhabditis elegans ]

Gene ID: 181276, updated on 2-Nov-2024

Summary

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Official Symbol
pgp-5
Official Full Name
P-GlycoProtein related
Primary source
WormBase:WBGene00003999
Locus tag
CELE_C05A9.1
See related
AllianceGenome:WB:WBGene00003999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in several processes, including defense response to bacterium; response to nematicide; and stress response to cadmium ion. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pgp-5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
18
Sequence:
Chromosome: X; NC_003284.9 (10854216..10859297, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P-GlycoProtein related Neighboring gene ncRNA Neighboring gene P-GlycoProtein related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Burkholderia pseudomallei kills Caenorhabditis elegans through virulence mechanisms distinct from intestinal lumen colonization. Ooi SK, et al. Virulence, 2012 Oct 1. PMID 23076282, Free PMC Article
  2. Ecotoxicogenomic analysis of stress induced on Caenorhabditis elegans in heavy metal contaminated soil after nZVI treatment. Fajardo C, et al. Chemosphere, 2020 Sep. PMID 32957299
  3. Intoxication vs. infection: a decade of studying Burkholderia pseudomallei virulence in a simple infection model. Day SR, et al. Virulence, 2012 Oct 1. PMID 23211680, Free PMC Article
  4. Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin. Ardelli BF, et al. Vet Parasitol, 2013 Jan 31. PMID 23062691
  5. WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans. Snoek BL, et al. Database (Oxford), 2020 Jan 1. PMID 31960906, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables efflux transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nematicide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stress response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stress response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress response to copper ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stress response to copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
P-GlycoProtein related
NP_001257116.1
  • Product from WormBase gene class pgp;
    Confirmed by transcript evidence
NP_001257117.1
  • Product from WormBase gene class pgp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10854216..10859297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270187.3 → NP_001257116.1  P-GlycoProtein related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257116.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17645
    Conserved Domains (3) summary
    cd03249
    Location:374 → 611
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:27 → 1241
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    cl00549
    Location:41 → 322
    ABC_membrane; ABC transporter transmembrane region

  2. NM_001270188.3 → NP_001257117.1  P-GlycoProtein related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257117.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6VQ78
    Conserved Domains (3) summary
    cd03249
    Location:282 → 519
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:1 → 1149
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    cl00549
    Location:1 → 230
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
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