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DVL3 dishevelled segment polarity protein 3 [ Homo sapiens (human) ]

Gene ID: 1857, updated on 2-Nov-2024

Summary

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Official Symbol
DVL3provided by HGNC
Official Full Name
dishevelled segment polarity protein 3provided by HGNC
Primary source
HGNC:HGNC:3087
See related
Ensembl:ENSG00000161202 MIM:601368; AllianceGenome:HGNC:3087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRS3
Summary
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 25.5), endometrium (RPKM 18.5) and 25 other tissues See more
Orthologs
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Genomic context

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See DVL3 in Genome Data Viewer
Location:
3q27.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (184155377..184173614)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (186964902..186982556)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183873165..183891402)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20902 Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14955 Neighboring gene ribosomal protein S3 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:183873749-183874626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:183874627-183875502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:183878685-183879185 Neighboring gene Sharpr-MPRA regulatory region 1463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14957 Neighboring gene Sharpr-MPRA regulatory region 464 Neighboring gene adaptor related protein complex 2 subunit mu 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:183900972-183901486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:183902780-183903494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20904 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:183908066-183909265 Neighboring gene ATP binding cassette subfamily F member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Dishevelled Segment Polarity Protein 3 (DVL3) Induced by Bacterial LPS Promotes the Proliferation and Migration of Prostate Cancer Cells through the TLR4 Pathway. Zhang Y, et al. Arch Esp Urol, 2024 Mar. PMID 38583012
  2. Silencing DVL3 defeats MTX resistance and attenuates stemness via Notch Signaling Pathway in colorectal cancer. Zhao Q, et al. Pathol Res Pract, 2020 Aug. PMID 32414668
  3. Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling. Gao S, et al. Cancer Res, 2014 Oct 15. PMID 25168481
  4. Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs. Hanáková K, et al. Cell Commun Signal, 2019 Dec 23. PMID 31870452, Free PMC Article
  5. Polymorphism and expression of the Dvl3 gene in the etiology of depressive disorder. Zajączkowska M, et al. Psychiatr Pol, 2020 Jun 30. PMID 33038884

See all (149) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.
    Title: WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.
  2. Dishevelled Segment Polarity Protein 3 (DVL3) Induced by Bacterial LPS Promotes the Proliferation and Migration of Prostate Cancer Cells through the TLR4 Pathway.
    Title: Dishevelled Segment Polarity Protein 3 (DVL3) Induced by Bacterial LPS Promotes the Proliferation and Migration of Prostate Cancer Cells through the TLR4 Pathway.
  3. Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/beta-catenin/c-Myc/SOX2 pathway in colorectal cancer.
    Title: Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer.
  4. RNA-Binding Protein MEX3A Interacting with DVL3 Stabilizes Wnt/beta-Catenin Signaling in Endometrial Carcinoma.
    Title: RNA-Binding Protein MEX3A Interacting with DVL3 Stabilizes Wnt/β-Catenin Signaling in Endometrial Carcinoma.
  5. Circ_0101802 Facilitates Colorectal Cancer Progression Depending on the Regulation of miR-665/DVL3 Signaling.
    Title: Circ_0101802 Facilitates Colorectal Cancer Progression Depending on the Regulation of miR-665/DVL3 Signaling.
  6. Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway.
    Title: Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway.
  7. DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts.
    Title: DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts.
  8. The Gender-Specific Interaction of DVL3 and GSK3beta Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
    Title: The Gender-Specific Interaction of DVL3 and GSK3β Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
  9. Clinical and molecular characterization of four patients with Robinow syndrome from different families.
    Title: Clinical and molecular characterization of four patients with Robinow syndrome from different families.
  10. DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.
    Title: DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Autosomal dominant Robinow syndrome 3
MedGen: C4225164 OMIM: 616894 GeneReviews: Autosomal Dominant Robinow Syndrome
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EBI GWAS Catalog

Description
A mega-analysis of genome-wide association studies for major depressive disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables frizzled binding TAS
Traceable Author Statement
more info
 PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in non-canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
segment polarity protein dishevelled homolog DVL-3
Names
dishevelled 3 (homologous to Drosophila dsh)
dishevelled, dsh homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046860.1 RefSeqGene

    Range
    5067..23304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1269

mRNA and Protein(s)

  1. NM_004423.4 → NP_004414.3  segment polarity protein dishevelled homolog DVL-3

    See identical proteins and their annotated locations for NP_004414.3

    Status: REVIEWED

    Source sequence(s)
    AC131235, D86963, U75651
    Consensus CDS
    CCDS3253.1
    UniProtKB/Swiss-Prot
    B4E3E5, D3DNT0, O14642, Q13531, Q8N5E9, Q92607, Q92997
    UniProtKB/TrEMBL
    Q8WVA8
    Related
    ENSP00000316054.3, ENST00000313143.9
    Conserved Domains (5) summary
    smart00021
    Location:1 → 82
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:247 → 334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:413 → 496
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:92 → 245
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:500 → 706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    184155377..184173614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    186964902..186982556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92997.2 GenPept UniProtKB/Swiss-Prot:Q92997

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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