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kqt-3 Potassium voltage-gated channel subfamily KQT member 1 [ Caenorhabditis elegans ]

Gene ID: 191699, updated on 2-Nov-2024

Summary

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Official Symbol
kqt-3
Official Full Name
Potassium voltage-gated channel subfamily KQT member 1
Primary source
WormBase:WBGene00002235
Locus tag
CELE_Y54G9A.3
See related
AllianceGenome:WB:WBGene00002235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables potassium channel activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and potassium ion transport. Predicted to be located in plasma membrane and synapse. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in head neurons; intestine; and sensory neurons. Used to study Jervell-Lange Nielsen syndrome and long QT syndrome. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); long QT syndrome (multiple); and type 2 diabetes mellitus. Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kqt-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (13703873..13712898)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase;DNA-directed RNA polymerase subunit Neighboring gene ncRNA Neighboring gene Zinc transporter ZIP3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Resolving a contradiction: full gene deletion of kqt-3 by CRISPR does not lead to pharyngeal pumping defects. Bauer R, et al. MicroPubl Biol, 2019 Jul 25. PMID 32550436, Free PMC Article
  2. KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation. Wei AD, et al. J Biol Chem, 2005 Jun 3. PMID 15797864
  3. Cold acclimation via the KQT-2 potassium channel is modulated by oxygen in Caenorhabditis elegans. Okahata M, et al. Sci Adv, 2019 Feb. PMID 30775442, Free PMC Article
  4. Efficient isolation of targeted Caenorhabditis elegans deletion strains using highly thermostable restriction endonucleases and PCR. Wei A, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384612, Free PMC Article
  5. Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program. Nehrke K, et al. Am J Physiol Cell Physiol, 2008 Jan. PMID 17942636

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Potassium voltage-gated channel subfamily KQT member 1
NP_001254403.1
  • Confirmed by transcript evidence
NP_001254404.1
  • Partially confirmed by transcript evidence
NP_001254405.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13703873..13712898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267474.5 → NP_001254403.1  Potassium voltage-gated channel subfamily KQT member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254403.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWG9
    Conserved Domains (3) summary
    pfam00520
    Location:108 → 313
    Ion_trans; Ion transport protein
    pfam03520
    Location:460 → 560
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:224 → 303
    Ion_trans_2; Ion channel

  2. NM_001267475.3 → NP_001254404.1  Potassium voltage-gated channel subfamily KQT member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254404.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7FAS2
    Conserved Domains (3) summary
    pfam00520
    Location:104 → 309
    Ion_trans; Ion transport protein
    pfam03520
    Location:456 → 556
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:220 → 299
    Ion_trans_2; Ion channel

  3. NM_001267476.3 → NP_001254405.1  Potassium voltage-gated channel subfamily KQT member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254405.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE44
    Conserved Domains (3) summary
    pfam00520
    Location:67 → 272
    Ion_trans; Ion transport protein
    pfam03520
    Location:419 → 519
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:183 → 262
    Ion_trans_2; Ion channel
Nucleotide Protein
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