uxs1 UDP-glucuronate decarboxylase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uxs1provided by ZNC
Official Full Name: UDP-glucuronate decarboxylase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-020419-37
See related: Ensembl:ENSDARG00000056102 AllianceGenome:ZFIN:ZDB-GENE-020419-37
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj36b08; CHUNP6891; zgc:91980; wu:fj36b08
Summary: Enables UDP-glucuronate decarboxylase activity. Acts upstream of or within several processes, including cartilage development; extracellular matrix organization; and proteoglycan biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including cartilage element; head; mesenchyme; perichondrium; and yolk syncytial layer. Orthologous to human UXS1 (UDP-glucuronate decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (6255933..6370693)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (6277948..6392708)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of chondroitin sulfate and heparan sulfate biosynthesis in zebrafish larvae homozygous for mutations in ext2, extl3, uxs1, or b3gat3
Title: On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis.
These results show that uxs1 transcript is localized in a pattern consistent with the mutant craniofacial phenotype, and that transcript instability may contribute to the loss of uxs1 function in uxs1hi3357 larvae.
Title: UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton.

Submit: New GeneRIF Correction

General gene information

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Markers

fj36b08.x1 (e-PCR)
- UniSTS:188474

fd09d11.y1 (e-PCR)
- UniSTS:195069

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables UDP-glucuronate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucuronate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucuronate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within D-xylose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-D-xylose biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondroitin sulfate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucuronic acid decarboxylase 1

Names: UXS-1

NP_775349.2

EC 4.1.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173242.2 → NP_775349.2 UDP-glucuronic acid decarboxylase 1

See identical proteins and their annotated locations for NP_775349.2

Status: VALIDATED

Source sequence(s)

CU639407, CU855778, FP102050

UniProtKB/Swiss-Prot

Q6GMI9, Q8JHG1

Related

ENSDARP00000072986.5, ENSDART00000078525.6

Conserved Domains (3) summary

cd05230
Location:87 → 389

UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs

COG0451
Location:87 → 394

WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]

pfam11803
Location:2 → 76

UXS1_N; UDP-glucuronate decarboxylase N-terminal