b3gat3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: b3gat3provided by ZNC
Official Full Name: beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)provided by ZNC
Primary source: ZFIN:ZDB-GENE-020419-3
See related: Ensembl:ENSDARG00000001939 AllianceGenome:ZFIN:ZDB-GENE-020419-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fe01c06; CHUNP6865; wu:fe01c06; zgc:112070
Summary: Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Acts upstream of or within cartilage development; extracellular matrix organization; and proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Larsen-like syndrome B3GAT3 type. Orthologous to human B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (25015273..25027236)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (24744116..24756079)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of chondroitin sulfate and heparan sulfate biosynthesis in zebrafish larvae homozygous for mutations in ext2, extl3, uxs1, or b3gat3
Title: On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

AW171178 (e-PCR)
- UniSTS:205850

fe01c06.x1 (e-PCR)
- UniSTS:195904

fb97e08.x1 (e-PCR)
- UniSTS:203591

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

Names: 3-glucuronyltransferase 3; beta3-glucuronyltransferase

NP_001015059.2

EC 2.4.1.135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015059.2 → NP_001015059.2 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

Status: VALIDATED

Source sequence(s)

AL954715, BX547932, CU856512

UniProtKB/TrEMBL

A0A8M1N560, F8W289

Related

ENSDARP00000124815.1, ENSDART00000149966.3

Conserved Domains (1) summary

cd00218
Location:72 → 308

GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis