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ZNF585A zinc finger protein 585A [ Homo sapiens (human) ]

Gene ID: 199704, updated on 28-Oct-2024

Summary

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Official Symbol
ZNF585Aprovided by HGNC
Official Full Name
zinc finger protein 585Aprovided by HGNC
Primary source
HGNC:HGNC:26305
See related
Ensembl:ENSG00000196967 AllianceGenome:HGNC:26305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Zfp27
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thyroid (RPKM 3.0), testis (RPKM 2.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF585A in Genome Data Viewer
Location:
19q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37145540..37172695, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39820506..39847661, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37636442..37663597, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene zinc finger protein 568 Neighboring gene zinc finger protein 420 Neighboring gene uncharacterized LOC105372390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14538 Neighboring gene Sharpr-MPRA regulatory region 11816 Neighboring gene zinc finger protein 585B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14540 Neighboring gene zinc finger protein 383

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  2. A dual-activity topoisomerase complex regulates mRNA translation and turnover. Su S, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35748872, Free PMC Article
  3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23765, FLJ25829, FLJ31827

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 585A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288800.2 → NP_001275729.1  zinc finger protein 585A isoform b

    See identical proteins and their annotated locations for NP_001275729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (b).
    Source sequence(s)
    AC012309, BC063820, DA990390
    Consensus CDS
    CCDS74353.1
    UniProtKB/Swiss-Prot
    Q6P3V2, Q8TE95, Q96MV3
    Related
    ENSP00000292841.7, ENST00000292841.10
    Conserved Domains (6) summary
    smart00349
    Location:27 → 85
    KRAB; krueppel associated box
    COG5048
    Location:184 → 529
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:328 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:27 → 66
    KRAB; KRAB box
    pfam13465
    Location:705 → 728
    zf-H2C2_2; Zinc-finger double domain

  2. NM_152655.4 → NP_689868.1  zinc finger protein 585A isoform a

    See identical proteins and their annotated locations for NP_689868.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an additional exon in the 5' region, which results in translation intiation at a downstream AUG, compared to variant 3. The resulting isoform (a) has a shorter N-terminus, compared to isoform b. Both variants 1 and 2 encode the same isoform a.
    Source sequence(s)
    AC012309, AK074345, DA738522, DA990390
    Consensus CDS
    CCDS12499.1
    UniProtKB/TrEMBL
    A0A0C4DFY4
    Related
    ENSP00000349440.3, ENST00000356958.8
    Conserved Domains (4) summary
    COG5048
    Location:129 → 474
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:273 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:650 → 673
    zf-H2C2_2; Zinc-finger double domain

  3. NM_199126.3 → NP_954577.1  zinc finger protein 585A isoform a

    See identical proteins and their annotated locations for NP_954577.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon and an additional exon in the 5' region, which results in translation intiation at a downstream AUG, compared to variant 3. The resulting isoform (a) has a shorter N-terminus, compared to isoform b. Both variants 1 and 2 encode the same isoform a.
    Source sequence(s)
    AC012309, BC052956, DB454691
    Consensus CDS
    CCDS12499.1
    UniProtKB/TrEMBL
    A0A0C4DFY4
    Related
    ENSP00000375998.1, ENST00000392157.2
    Conserved Domains (4) summary
    COG5048
    Location:129 → 474
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:273 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:650 → 673
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_110152.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several exons and its transcription extends past a splice site that is used in variant 3. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AF086428, AW015367, DA990390
    Related
    ENST00000588354.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37145540..37172695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39820506..39847661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P3V2.2 GenPept UniProtKB/Swiss-Prot:Q6P3V2

Gene LinkOut

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