U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Scrg1 scrapie responsive gene 1 [ Mus musculus (house mouse) ]

Gene ID: 20284, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Scrg1provided by MGI
Official Full Name
scrapie responsive gene 1provided by MGI
Primary source
MGI:MGI:1328308
See related
Ensembl:ENSMUSG00000031610 AllianceGenome:MGI:1328308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in mesenchymal stem cell proliferation. Located in Golgi apparatus and neuron projection terminus. Is expressed in several structures, including central nervous system; cranium; foot bone; lung; and sternum. Orthologous to human SCRG1 (stimulator of chondrogenesis 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 8.4), frontal lobe adult (RPKM 7.3) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Scrg1 in Genome Data Viewer
Location:
8 B2; 8 29.8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (57909093..57932441)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (57455882..57479360)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21526 Neighboring gene predicted gene, 34099 Neighboring gene mannosidase 2, alpha 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21527 Neighboring gene RIKEN cDNA 2500002B13 gene Neighboring gene STARR-positive B cell enhancer ABC_E1755 Neighboring gene STARR-seq mESC enhancer starr_21528 Neighboring gene sin3 associated polypeptide

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Scrg1 is induced in TSE and brain injuries, and associated with autophagy. Dron M, et al. Eur J Neurosci, 2005 Jul. PMID 16029203
  2. Characterization of the human analogue of a Scrapie-responsive gene. Dron M, et al. J Biol Chem, 1998 Jul 17. PMID 9660755
  3. Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7). Durkin ME, et al. Gene, 2002 Apr 17. PMID 12034501
  4. Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. Dron M, et al. Genomics, 2000 Nov 15. PMID 11087671
  5. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Dandoy-Dron F, et al. J Biol Chem, 1998 Mar 27. PMID 9516475

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taken together, our results indicate that Scrg1 is associated with neurodegenerative processes in TSE, but is not directly linked to dysregulation of prion protein.
    Title: Scrg1 is induced in TSE and brain injuries, and associated with autophagy.
  2. Scrg1 is associated with the secretory pathway of neuronal cells.
    Title: Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mesenchymal stem cell proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
scrapie-responsive protein 1
Names
scRG-1
scrapie responsive protein one
scrapie-responsive gene 1 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424875.1 → NP_001411804.1  scrapie-responsive protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC128700, AC130841
    UniProtKB/Swiss-Prot
    O88745
    UniProtKB/TrEMBL
    Q543T5

  2. NM_009136.4 → NP_033162.1  scrapie-responsive protein 1 precursor

    See identical proteins and their annotated locations for NP_033162.1

    Status: VALIDATED

    Source sequence(s)
    AC128700, AC130841
    Consensus CDS
    CCDS40342.1
    UniProtKB/Swiss-Prot
    O88745
    UniProtKB/TrEMBL
    Q543T5
    Related
    ENSMUSP00000034023.4, ENSMUST00000034023.4
    Conserved Domains (1) summary
    pfam15224
    Location:22 → 97
    SCRG1; Scrapie-responsive protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    57909093..57932441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88745.1 GenPept UniProtKB/Swiss-Prot:O88745

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools