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Ankrd33 ankyrin repeat domain 33 [ Mus musculus (house mouse) ]

Gene ID: 208258, updated on 2-Nov-2024

Summary

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Official Symbol
Ankrd33provided by MGI
Official Full Name
ankyrin repeat domain 33provided by MGI
Primary source
MGI:MGI:2443398
See related
Ensembl:ENSMUSG00000047034 AllianceGenome:MGI:2443398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Panky; Panky-a; A930021G21Rik
Summary
Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in cytosol and nucleus. Is expressed in pineal gland; retina; retina inner nuclear layer; retina outer nuclear layer; and testis. Orthologous to human ANKRD33 (ankyrin repeat domain 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Ankrd33 in Genome Data Viewer
Location:
15 F1; 15 56.39 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101013625..101017923)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101115744..101120028)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene fidgetin-like 2 Neighboring gene predicted gene, 53912 Neighboring gene predicted gene, 41402 Neighboring gene activin A receptor, type II-like 1 Neighboring gene activin A receptor, type 1B Neighboring gene STARR-positive B cell enhancer ABC_E4151 Neighboring gene microRNA 6962

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes. Sanuki R, et al. FEBS Lett, 2010 Feb 19. PMID 20026326
  2. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Liu P, et al. Nat Genet, 2006 Aug. PMID 16862160
  3. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
  4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies isolated Panky/Ankrd33, a gene encoding an ankyrin repeat-containing protein and that PANKY inhibited the DNA-binding activity of CRX.
    Title: Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC31569

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
photoreceptor ankyrin repeat protein
Names
ankyrin repeat domain-containing protein 33
photorecptor ankyrin repeat protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355656.1 → NP_001342585.1  photoreceptor ankyrin repeat protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104834
    Conserved Domains (2) summary
    cd00204
    Location:1 → 118
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:29 → 62
    ANK; ANK repeat [structural motif]

  2. NM_001374225.1 → NP_001361154.1  photoreceptor ankyrin repeat protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104834
    UniProtKB/Swiss-Prot
    D5G1T0, Q8BXP4, Q8BXP5, Q8R1Z1
    Related
    ENSMUSP00000155584.2, ENSMUST00000229954.2
    Conserved Domains (4) summary
    sd00045
    Location:53 → 85
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:58 → 153
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:18 → 73
    Ank_4; Ankyrin repeats (many copies)
    cl39094
    Location:127 → 192
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_144790.1 → NP_659039.1  photoreceptor ankyrin repeat protein isoform 1

    See identical proteins and their annotated locations for NP_659039.1

    Status: VALIDATED

    Source sequence(s)
    BC022726
    Consensus CDS
    CCDS27845.1
    UniProtKB/Swiss-Prot
    Q8BXP5
    Related
    ENSMUSP00000067028.7, ENSMUST00000070875.8
    Conserved Domains (3) summary
    cd00204
    Location:7 → 128
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:10 → 105
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:5 → 37
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101013625..101017923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159294.1 → XP_036015187.1  photoreceptor ankyrin repeat protein isoform X1

    Conserved Domains (2) summary
    sd00045
    Location:29 → 62
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1 → 95
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXP5.2 GenPept UniProtKB/Swiss-Prot:Q8BXP5

Gene LinkOut

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