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Myo5c myosin VC [ Mus musculus (house mouse) ]

Gene ID: 208943, updated on 28-Oct-2024

Summary

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Official Symbol
Myo5cprovided by MGI
Official Full Name
myosin VCprovided by MGI
Primary source
MGI:MGI:2442485
See related
Ensembl:ENSMUSG00000033590 AllianceGenome:MGI:2442485
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330029I24; 9130003O20Rik
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to act upstream of or within establishment of secretory granule localization. Predicted to be located in secretory granule. Predicted to be active in several cellular components, including actin cytoskeleton; cytoplasm; and vesicle. Is expressed in several structures, including gut; liver; respiratory system; sensory organ; and submandibular gland primordium. Orthologous to human MYO5C (myosin VC). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in colon adult (RPKM 9.6), lung adult (RPKM 7.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Myo5c in Genome Data Viewer
Location:
9 D; 9 42.3 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75139252..75212733)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75231969..75307485)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene apoptosis inhibitor 5 pseudogene Neighboring gene myosin VA Neighboring gene branched chain ketoacid dehydrogenase E1, beta polypeptide pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11749 Neighboring gene predicted gene, 33750 Neighboring gene STARR-seq mESC enhancer starr_24658 Neighboring gene predicted gene, 53503 Neighboring gene predicted gene, 19531 Neighboring gene guanine nucleotide binding protein (G protein), beta 5 Neighboring gene Bcl2-like 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Small teams of myosin Vc motors coordinate their stepping for efficient cargo transport on actin bundles. Krementsova EB, et al. J Biol Chem, 2017 Jun 30. PMID 28476885, Free PMC Article
  2. Myosin Vc is a molecular motor that functions in secretory granule trafficking. Jacobs DT, et al. Mol Biol Cell, 2009 Nov. PMID 19741097, Free PMC Article
  3. Analyses of the circadian clock genes expression in whole embryos and maternal major tissues of mice. Cao X, et al. J Mol Histol, 2022 Apr. PMID 35149920
  4. The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. Harten SK, et al. BMC Biol, 2015 Mar 26. PMID 25857663, Free PMC Article
  5. Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Fang Q, et al. Sci Rep, 2019 Mar 4. PMID 30833597, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study provides a molecular basis to explain how teams of myoVc motors are suited to transport cargos such as zymogen granules on actin bundles.
    Title: Small teams of myosin Vc motors coordinate their stepping for efficient cargo transport on actin bundles.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of secretory granule localization ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
unconventional myosin-Vc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081322.1 → NP_001074791.1  unconventional myosin-Vc

    Status: PROVISIONAL

    Source sequence(s)
    AC133947
    Consensus CDS
    CCDS40691.1
    UniProtKB/TrEMBL
    E9Q1F5
    Related
    ENSMUSP00000042229.7, ENSMUST00000036555.8
    Conserved Domains (9) summary
    smart00015
    Location:830 → 851
    IQ; Calmodulin-binding motif
    smart00242
    Location:62 → 752
    MYSc; Myosin. Large ATPases
    COG1340
    Location:890 → 1150
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd15476
    Location:1369 → 1736
    Myo5c_CBD; Cargo binding domain of myosin 5C
    cd01380
    Location:81 → 741
    MYSc_Myo5; class V myosin, motor domain
    pfam02736
    Location:12 → 48
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:1001 → 1010
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:961 → 1030
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:952 → 1096
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75139252..75212733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510939.4 → XP_006511002.1  unconventional myosin-Vc isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:848 → 1155
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01380
    Location:81 → 741
    MYSc_Myo5; class V myosin, motor domain
    pfam00612
    Location:831 → 851
    IQ; IQ calmodulin-binding motif

  2. XM_006510940.5 → XP_006511003.1  unconventional myosin-Vc isoform X3

    Conserved Domains (3) summary
    TIGR02169
    Location:922 → 1230
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd01380
    Location:81 → 741
    MYSc_Myo5; class V myosin, motor domain
    pfam12128
    Location:767 → 1043
    DUF3584; Protein of unknown function (DUF3584)

  3. XM_036154772.1 → XP_036010665.1  unconventional myosin-Vc isoform X4

    UniProtKB/TrEMBL
    Q8BWY8
    Conserved Domains (2) summary
    cd01380
    Location:81 → 741
    MYSc_Myo5; class V myosin, motor domain
    pfam00612
    Location:831 → 851
    IQ; IQ calmodulin-binding motif

  4. XM_006510936.5 → XP_006510999.1  unconventional myosin-Vc isoform X1

    See identical proteins and their annotated locations for XP_006510999.1

    Conserved Domains (5) summary
    cd15476
    Location:1376 → 1743
    Myo5c_CBD; Cargo binding domain of myosin 5C
    TIGR02169
    Location:922 → 1276
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd01380
    Location:81 → 741
    MYSc_Myo5; class V myosin, motor domain
    pfam00769
    Location:1220 → 1354
    ERM; Ezrin/radixin/moesin family
    pfam12128
    Location:767 → 1043
    DUF3584; Protein of unknown function (DUF3584)

  5. XM_011242693.4 → XP_011240995.1  unconventional myosin-Vc isoform X1

    See identical proteins and their annotated locations for XP_011240995.1

    Conserved Domains (5) summary
    cd15476
    Location:1376 → 1743
    Myo5c_CBD; Cargo binding domain of myosin 5C
    TIGR02169
    Location:922 → 1276
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd01380
    Location:81 → 741
    MYSc_Myo5; class V myosin, motor domain
    pfam00769
    Location:1220 → 1354
    ERM; Ezrin/radixin/moesin family
    pfam12128
    Location:767 → 1043
    DUF3584; Protein of unknown function (DUF3584)

  6. XM_006510935.5 → XP_006510998.1  unconventional myosin-Vc isoform X1

    See identical proteins and their annotated locations for XP_006510998.1

    Conserved Domains (5) summary
    cd15476
    Location:1376 → 1743
    Myo5c_CBD; Cargo binding domain of myosin 5C
    TIGR02169
    Location:922 → 1276
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd01380
    Location:81 → 741
    MYSc_Myo5; class V myosin, motor domain
    pfam00769
    Location:1220 → 1354
    ERM; Ezrin/radixin/moesin family
    pfam12128
    Location:767 → 1043
    DUF3584; Protein of unknown function (DUF3584)

RNA

  1. XR_001778835.3 RNA Sequence

  2. XR_004935364.1 RNA Sequence

  3. XR_379407.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145366.1: Suppressed sequence

    Description
    NM_145366.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

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