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Tmc7 transmembrane channel-like gene family 7 [ Mus musculus (house mouse) ]

Gene ID: 209760, updated on 2-Nov-2024

Summary

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Official Symbol
Tmc7provided by MGI
Official Full Name
transmembrane channel-like gene family 7provided by MGI
Primary source
MGI:MGI:2443317
See related
Ensembl:ENSMUSG00000042246 AllianceGenome:MGI:2443317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C230064B05; 1700030H01Rik; C630024K23Rik
Summary
Enables ion channel inhibitor activity. Involved in sensory perception of mechanical stimulus. Predicted to be located in plasma membrane. Orthologous to human TMC7 (transmembrane channel like 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 39.3), cerebellum adult (RPKM 4.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Tmc7 in Genome Data Viewer
Location:
7 F1; 7 63.44 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118135064..118184052, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118535841..118584829, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51516 Neighboring gene demethyl-Q 7 Neighboring gene STARR-positive B cell enhancer ABC_E1093 Neighboring gene RIKEN cDNA B230311B06 gene Neighboring gene transmembrane channel-like gene family 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction. Zhang X, et al. Cell Rep, 2024 Apr 23. PMID 38568807
  2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Kurima K, et al. Genomics, 2003 Sep. PMID 12906855
  3. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. Keresztes G, et al. BMC Genomics, 2003 Jun 17. PMID 12812529, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ion channel inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in sensory perception of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane channel-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172476.5 → NP_766064.2  transmembrane channel-like protein 7

    See identical proteins and their annotated locations for NP_766064.2

    Status: VALIDATED

    Source sequence(s)
    AC122912, AC124444
    Consensus CDS
    CCDS21772.1
    UniProtKB/Swiss-Prot
    Q7TN59, Q7TQ66, Q8C428, Q8C4C3
    Related
    ENSMUSP00000046927.5, ENSMUST00000044195.6
    Conserved Domains (1) summary
    pfam07810
    Location:489 → 590
    TMC; TMC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    118135064..118184052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507550.5 → XP_006507613.1  transmembrane channel-like protein 7 isoform X1

    Conserved Domains (1) summary
    pfam07810
    Location:376 → 487
    TMC; TMC domain

  2. XM_036152862.1 → XP_036008755.1  transmembrane channel-like protein 7 isoform X1

    Conserved Domains (1) summary
    pfam07810
    Location:376 → 487
    TMC; TMC domain

RNA

  1. XR_003946428.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C428.1 GenPept UniProtKB/Swiss-Prot:Q8C428

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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