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ETS2 ETS proto-oncogene 2, transcription factor [ Homo sapiens (human) ]

Gene ID: 2114, updated on 2-Nov-2024

Summary

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Official Symbol
ETS2provided by HGNC
Official Full Name
ETS proto-oncogene 2, transcription factorprovided by HGNC
Primary source
HGNC:HGNC:3489
See related
Ensembl:ENSG00000157557 MIM:164740; AllianceGenome:HGNC:3489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETS2IT1
Summary
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in spleen (RPKM 50.4), small intestine (RPKM 39.5) and 22 other tissues See more
Orthologs
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Genomic context

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See ETS2 in Genome Data Viewer
Location:
21q22.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (38805183..38824955)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (37188973..37208712)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40177107..40196879)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18458 Neighboring gene uncharacterized LOC107985480 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40159061-40160260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:40176652-40177152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13316 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:40182837-40184036 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:40185951-40187150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:40194325-40194862 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40203265-40204464 Neighboring gene uncharacterized LOC101928398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13317 Neighboring gene ETS2 antisense RNA 1 Neighboring gene ribosomal protein SA pseudogene 64

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators. Boulukos KE, et al. Genes Dev, 1990 Mar. PMID 2186967
  2. Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2. Newman JA, et al. J Biol Chem, 2015 Mar 27. PMID 25670864, Free PMC Article
  3. Role for Ets-2(Thr-72) transcription factor in stage-specific thymocyte development and survival. Fisher IB, et al. J Biol Chem, 2012 Feb 17. PMID 22128184, Free PMC Article
  4. Differential allelic distribution of V-ets erythroblastosis virus E26 oncogene homolog2 (ETS2) functional polymorphisms in different group of patients. Chatterjee A, et al. Gene Expr, 2010. PMID 21526717, Free PMC Article
  5. A genetic variation in microRNA target site of ETS2 is associated with clinical outcomes of paclitaxel-cisplatin chemotherapy in non-small cell lung cancer. Hong MJ, et al. Oncotarget, 2016 Mar 29. PMID 26893365, Free PMC Article

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NNMT switches the proangiogenic phenotype of cancer-associated fibroblasts via epigenetically regulating ETS2/VEGFA axis.
    Title: NNMT switches the proangiogenic phenotype of cancer-associated fibroblasts via epigenetically regulating ETS2/VEGFA axis.
  2. ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma.
    Title: ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma.
  3. A disease-associated gene desert directs macrophage inflammation through ETS2.
    Title: A disease-associated gene desert directs macrophage inflammation through ETS2.
  4. USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.
    Title: USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.
  5. ETS2 promotes cardiomyocyte apoptosis and autophagy in heart failure by regulating lncRNA TUG1/miR-129-5p/ATG7 axis.
    Title: ETS2 promotes cardiomyocyte apoptosis and autophagy in heart failure by regulating lncRNA TUG1/miR-129-5p/ATG7 axis.
  6. ETS2 alleviates acute-on-chronic liver failure by suppressing excessive inflammation.
    Title: ETS2 alleviates acute-on-chronic liver failure by suppressing excessive inflammation.
  7. Suppression of USP7 negatively regulates the stability of ETS proto-oncogene 2 protein.
    Title: Suppression of USP7 negatively regulates the stability of ETS proto-oncogene 2 protein.
  8. A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models.
    Title: A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models.
  9. Codon Optimization, Cloning, Expression, Purification, and Secondary Structure Determination of Human ETS2 Transcription Factor.
    Title: Codon Optimization, Cloning, Expression, Purification, and Secondary Structure Determination of Human ETS2 Transcription Factor.
  10. Transcription factor Ets-2 regulates the expression of key lymphotropic factors.
    Title: Transcription factor Ets-2 regulates the expression of key lymphotropic factors.
Submit: New GeneRIF Correction See all GeneRIFs (89)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog
Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of v-ets erythroblastosis virus E26 oncogene homolog 2 (avian, ETS2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear glucocorticoid receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ectodermal cell fate commitment IEA
Inferred from Electronic Annotation
more info
  
involved_in mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in primitive streak formation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal system development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein C-ets-2
Names
oncogene ETS-2
v-ets avian erythroblastosis virus E2 oncogene homolog 2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
v-ets erythroblastosis virus E26 oncogene homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256295.2 → NP_001243224.1  protein C-ets-2 isoform 2

    See identical proteins and their annotated locations for NP_001243224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AK000535, AK096841, AP001040, AP001041
    Conserved Domains (3) summary
    cd08543
    Location:225 → 313
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:502 → 586
    ETS; erythroblast transformation specific domain
    pfam05350
    Location:39 → 143
    GSK-3_bind; Glycogen synthase kinase-3 binding

  2. NM_005239.6 → NP_005230.1  protein C-ets-2 isoform 1

    See identical proteins and their annotated locations for NP_005230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    AA452482, AK000535, BC042954, J04102
    Consensus CDS
    CCDS13659.1
    UniProtKB/Swiss-Prot
    A6NM68, D3DSH6, P15036, Q53Y89
    UniProtKB/TrEMBL
    A0A590UJP9
    Related
    ENSP00000354194.3, ENST00000360938.8
    Conserved Domains (2) summary
    cd08543
    Location:85 → 173
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:362 → 446
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    38805183..38824955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260935.2 → XP_005260992.1  protein C-ets-2 isoform X1

    See identical proteins and their annotated locations for XP_005260992.1

    UniProtKB/Swiss-Prot
    A6NM68, D3DSH6, P15036, Q53Y89
    UniProtKB/TrEMBL
    A0A590UJP9
    Conserved Domains (2) summary
    cd08543
    Location:85 → 173
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:362 → 446
    ETS; erythroblast transformation specific domain

  2. XM_017028290.2 → XP_016883779.1  protein C-ets-2 isoform X1

    UniProtKB/Swiss-Prot
    A6NM68, D3DSH6, P15036, Q53Y89
    UniProtKB/TrEMBL
    A0A590UJP9
    Conserved Domains (2) summary
    cd08543
    Location:85 → 173
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:362 → 446
    ETS; erythroblast transformation specific domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    37188973..37208712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324370.1 → XP_054180345.1  protein C-ets-2 isoform X1

    UniProtKB/Swiss-Prot
    A6NM68, D3DSH6, P15036, Q53Y89
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15036.1 GenPept UniProtKB/Swiss-Prot:P15036

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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