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Tagln transgelin [ Mus musculus (house mouse) ]

Gene ID: 21345, updated on 2-Nov-2024

Summary

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Official Symbol
Taglnprovided by MGI
Official Full Name
transgelinprovided by MGI
Primary source
MGI:MGI:106012
See related
Ensembl:ENSMUSG00000032085 AllianceGenome:MGI:106012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sm22; Sm22a; Ws310
Summary
This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis. [provided by RefSeq, Mar 2010]
Expression
Biased expression in bladder adult (RPKM 3112.1), stomach adult (RPKM 1002.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Tagln in Genome Data Viewer
Location:
9 A5.2; 9 25.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45840926..45847356, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45929628..45936058, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45655339-45655522 Neighboring gene beta-site APP cleaving enzyme 1 Neighboring gene ring finger protein 214 Neighboring gene predicted gene, 24646 Neighboring gene STARR-seq mESC enhancer starr_24009 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene RIKEN cDNA A830035O19 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SM22α Loss Contributes to Apoptosis of Vascular Smooth Muscle Cells via Macrophage-Derived circRasGEF1B. Lv P, et al. Oxid Med Cell Longev, 2021. PMID 33859778, Free PMC Article
  2. Transcriptome profiling reveals that the SM22α-regulated molecular pathways contribute to vascular pathology. Chen R, et al. J Mol Cell Cardiol, 2014 Jul. PMID 24735829
  3. SM22α cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury. Ito R, et al. Am J Physiol Lung Cell Mol Physiol, 2022 Aug 1. PMID 35762602, Free PMC Article
  4. The glomerular parietal epithelial cell's responses are influenced by SM22 alpha levels. Naito S, et al. BMC Nephrol, 2014 Nov 6. PMID 25376243, Free PMC Article
  5. Sm22α transcription occurs at the early onset of the cardiovascular system and the intron 1 is dispensable for its transcription in smooth muscle cells during mouse development. Yang M, et al. Int J Physiol Pathophysiol Pharmacol, 2010. PMID 20428474, Free PMC Article

See all (353) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of prolyl hydroxylase 1 and 2 in SM22alpha-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
    Title: Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
  2. Hypoxia-Inducible Factor-1alpha in SM22alpha-Expressing Cells Modulates Alveolarization.
    Title: Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.
  3. SM22alpha Deletion Contributes to Neurocognitive Impairment in Mice through Modulating Vascular Smooth Muscle Cell Phenotypes.
    Title: SM22α Deletion Contributes to Neurocognitive Impairment in Mice through Modulating Vascular Smooth Muscle Cell Phenotypes.
  4. SM22alpha cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury.
    Title: SM22α cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury.
  5. Deletion of SM22alpha disrupts the structure and function of caveolae and T-tubules in cardiomyocytes, contributing to heart failure.
    Title: Deletion of SM22α disrupts the structure and function of caveolae and T-tubules in cardiomyocytes, contributing to heart failure.
  6. Smooth muscle protein 22alpha-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors.
    Title: Smooth muscle protein 22α-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors.
  7. Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
    Title: Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
  8. The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis.
    Title: The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis.
  9. SM22alpha(+) vascular mural cells are essential for vessel stability in tumors and undergo phenotype transition regulated by Notch signaling.
    Title: SM22α(+) vascular mural cells are essential for vessel stability in tumors and undergo phenotype transition regulated by Notch signaling.
  10. Smooth muscle 22alpha deficiency impairs oxytocin-induced uterine contractility in mice at full-term pregnancy.
    Title: Smooth muscle 22α deficiency impairs oxytocin-induced uterine contractility in mice at full-term pregnancy.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
NOT acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transgelin
Names
SM22-alpha
Sm22alpha
actin-associated protein p27
smooth muscle protein 22-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011526.5 → NP_035656.1  transgelin

    See identical proteins and their annotated locations for NP_035656.1

    Status: REVIEWED

    Source sequence(s)
    AC122273, AK077235
    Consensus CDS
    CCDS23137.1
    UniProtKB/Swiss-Prot
    P37804, Q545W0
    Related
    ENSMUSP00000034590.3, ENSMUST00000034590.4
    Conserved Domains (3) summary
    COG5199
    Location:14 → 189
    SCP1; Calponin [Cytoskeleton]
    cd00014
    Location:25 → 137
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:175 → 198
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45840926..45847356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37804.3 GenPept UniProtKB/Swiss-Prot:P37804

Gene LinkOut

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