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ZNF25 zinc finger protein 25 [ Homo sapiens (human) ]

Gene ID: 219749, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF25provided by HGNC
Official Full Name
zinc finger protein 25provided by HGNC
Primary source
HGNC:HGNC:13043
See related
Ensembl:ENSG00000175395 MIM:194528; AllianceGenome:HGNC:13043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Zfp9; KOX19
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 11.8), adrenal (RPKM 6.3) and 24 other tissues See more
Orthologs
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Genomic context

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See ZNF25 in Genome Data Viewer
Location:
10p11.21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (37949573..37976647, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (37993572..38020648, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38238501..38265575, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 37C, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:38186151-38186679 Neighboring gene zinc finger protein 33C, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3272 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:38274009-38274157 Neighboring gene ZNF25 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3273 Neighboring gene zinc finger protein 33A Neighboring gene RNA, U6 small nuclear 795, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells. Twine NA, et al. BMC Genomics, 2016 Nov 4. PMID 27814695, Free PMC Article
  2. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10q. Guy J, et al. Hum Mol Genet, 2000 Aug 12. PMID 10942432
  3. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. Rousseau-Merck MF, et al. Genomics, 1992 Jul. PMID 1639412
  4. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. Guy J, et al. Genome Res, 2003 Feb. PMID 12566394, Free PMC Article
  5. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Tunnacliffe A, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464732, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study shows that the uncharacterized transcription factor, ZNF25, is associated with differentiation of hMSC to osteoblasts.
    Title: Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31890, DKFZp564C206

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 25
Names
zinc finger protein 25 (KOX 19)
zinc finger protein KOX19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329647.2 → NP_001316576.1  zinc finger protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AL117337
    Conserved Domains (5) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:148 → 457
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264 → 284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:248 → 273
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001329648.2 → NP_001316577.1  zinc finger protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform a, as do variants 1 and 3.
    Source sequence(s)
    AL117337
    Conserved Domains (5) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:148 → 457
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264 → 284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:248 → 273
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001329649.2 → NP_001316578.1  zinc finger protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform a, as do variants 1 and 2.
    Source sequence(s)
    AL117337, DA306585
    Conserved Domains (5) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:148 → 457
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264 → 284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:248 → 273
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001329650.2 → NP_001316579.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform b, as do variants 4, 6, 7, 8, and 9.
    Source sequence(s)
    AL117337
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:144 → 453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:244 → 269
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001329651.2 → NP_001316580.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform b, as do variants 4, 5, 7, 8, and 9.
    Source sequence(s)
    AL117337
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:144 → 453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:244 → 269
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001329652.2 → NP_001316581.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform b, as do variants 4, 5, 6, 8, and 9.
    Source sequence(s)
    AL117337
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:144 → 453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:244 → 269
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001329653.2 → NP_001316582.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes isoform b, as do variants 4, 5, 6, 7, and 9.
    Source sequence(s)
    AL117337
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:144 → 453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:244 → 269
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001329654.2 → NP_001316583.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes isoform b, as do variants 4-8.
    Source sequence(s)
    AL117337, DA113590
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:144 → 453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:244 → 269
    zf-H2C2_2; Zinc-finger double domain

  9. NM_001329655.2 → NP_001316584.1  zinc finger protein 25 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL117337, DA320329

  10. NM_001329656.2 → NP_001316585.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) encodes isoform d, as do variants 11-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:108 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  11. NM_001329657.2 → NP_001316586.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) encodes isoform d, as do variants 11 and 13-9.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:108 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  12. NM_001329658.2 → NP_001316587.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) encodes isoform d, as do variants 11-12 and 14-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:108 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  13. NM_001329659.2 → NP_001316588.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) encodes isoform d, as do variants 11-13 and 15-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:108 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  14. NM_001329660.2 → NP_001316589.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) encodes isoform d, as do variants 11-14 and 16-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:108 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  15. NM_001329661.2 → NP_001316590.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) encodes isoform d, as do variants 11-15 and 17-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:108 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  16. NM_001329662.2 → NP_001316591.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) encodes isoform d, as do variants 11-16 and 18-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:108 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  17. NM_001329663.2 → NP_001316592.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) encodes isoform d, as do variants 11-17 and 19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:108 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  18. NM_001329664.2 → NP_001316593.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) encodes isoform d, as do variants 11-18.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:108 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  19. NM_145011.4 → NP_659448.1  zinc finger protein 25 isoform b

    See identical proteins and their annotated locations for NP_659448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform b, as do variants 5-9.
    Source sequence(s)
    AL117337, BP229986
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
    Related
    ENSP00000302222.7, ENST00000302609.8
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:144 → 453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:244 → 269
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_138062.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337

  2. NR_138063.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337

  3. NR_138064.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337

  4. NR_138065.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337

  5. NR_138066.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337

  6. NR_138067.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337

  7. NR_138068.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337

  8. NR_138069.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337, DB042775

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    37949573..37976647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424716.1 → XP_047280672.1  zinc finger protein 25 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    37993572..38020648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365011.1 → XP_054220986.1  zinc finger protein 25 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17030.2 GenPept UniProtKB/Swiss-Prot:P17030

Gene LinkOut

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