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PHACTR1 phosphatase and actin regulator 1 [ Homo sapiens (human) ]

Gene ID: 221692, updated on 3-Apr-2024

Summary

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Official Symbol
PHACTR1provided by HGNC
Official Full Name
phosphatase and actin regulator 1provided by HGNC
Primary source
HGNC:HGNC:20990
See related
Ensembl:ENSG00000112137 MIM:608723; AllianceGenome:HGNC:20990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPEL; DEE70; RPEL1; EIEE70; dJ257A7.2
Summary
The protein encoded by this gene is a member of the phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are associated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Expression
Biased expression in brain (RPKM 12.6), bone marrow (RPKM 5.8) and 12 other tissues See more
Orthologs
mouse all
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Genomic context

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See PHACTR1 in Genome Data Viewer
Location:
6p24.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (12716767..13287837)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (12585196..13161093)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (12716999..13288069)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 7011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24019 Neighboring gene long intergenic non-protein coding RNA 2530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16923 Neighboring gene NANOG hESC enhancer GRCh37_chr6:12672164-12672665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:12673381-12673882 Neighboring gene uncharacterized LOC107984015 Neighboring gene uncharacterized LOC124901503 Neighboring gene uncharacterized LOC105374935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:12749187-12749871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:12749997-12750498 Neighboring gene uncharacterized LOC105374934 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:12851299-12851828 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:12887216-12887819 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:12956003-12956794 Neighboring gene uncharacterized LOC124901262 Neighboring gene TBC1D7-LOC100130357 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16924 Neighboring gene MPRA-validated peak5664 silencer Neighboring gene uncharacterized LOC105374933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16925 Neighboring gene Sharpr-MPRA regulatory region 805 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:13257894-13258394 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:13258395-13258895 Neighboring gene RNA, U1 small nuclear 11, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24021 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:13273523-13274722 Neighboring gene uncharacterized LOC100130357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24023 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:13307473-13308672 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13328608-13329114 Neighboring gene uncharacterized LOC124901261 Neighboring gene TBC1 domain family member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The association of polymorphism in PHACTR1 rs9349379 and rs12526453 with coronary artery atherosclerosis or coronary artery calcification. A systematic review. Koitsopoulos PG, et al. Coron Artery Dis, 2021 Aug 1. PMID 33660664
  2. Association of PHACTR1 intronic variants with the first myocardial infarction and their effect on PHACTR1 mRNA expression in PBMCs. Kuveljic J, et al. Gene, 2021 Apr 5. PMID 33460763
  3. Genetic Study of PHACTR1 and Fibromuscular Dysplasia, Meta-Analysis and Effects on Clinical Features of Patients: The ARCADIA-POL Study. Warchol-Celinska E, et al. Hypertension, 2020 Jul. PMID 32475314
  4. Associations between PHACTR1 gene polymorphisms and pulse pressure in Chinese Han population. Gu K, et al. Biosci Rep, 2020 Jun 26. PMID 32420588, Free PMC Article
  5. Phosphatase and actin regulator 1 rs9349379 polymorphism is associated with an elevated susceptibility to coronary artery disease: a meta-analysis. Sun X, et al. J Biol Regul Homeost Agents, 2019 May-Jun. PMID 31204462

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PHACTR1 modulates vascular compliance but not endothelial function: a translational study.
    Title: PHACTR1 modulates vascular compliance but not endothelial function: a translational study.
  2. PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction.
    Title: PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction.
  3. A Study of Associations Between rs9349379 (PHACTR1), rs2891168 (CDKN2B-AS), rs11838776 (COL4A2) and rs4880 (SOD2) Polymorphic Variants and Coronary Artery Disease in Iranian Population.
    Title: A Study of Associations Between rs9349379 (PHACTR1), rs2891168 (CDKN2B-AS), rs11838776 (COL4A2) and rs4880 (SOD2) Polymorphic Variants and Coronary Artery Disease in Iranian Population.
  4. The association of polymorphism in PHACTR1 rs9349379 and rs12526453 with coronary artery atherosclerosis or coronary artery calcification. A systematic review.
    Title: The association of polymorphism in PHACTR1 rs9349379 and rs12526453 with coronary artery atherosclerosis or coronary artery calcification. A systematic review.
  5. PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice.
    Title: PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice.
  6. Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis.
    Title: Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis.
  7. Genetic Study of PHACTR1 and Fibromuscular Dysplasia, Meta-Analysis and Effects on Clinical Features of Patients: The ARCADIA-POL Study.
    Title: Genetic Study of PHACTR1 and Fibromuscular Dysplasia, Meta-Analysis and Effects on Clinical Features of Patients: The ARCADIA-POL Study.
  8. Association of PHACTR1 intronic variants with the first myocardial infarction and their effect on PHACTR1 mRNA expression in PBMCs.
    Title: Association of PHACTR1 intronic variants with the first myocardial infarction and their effect on PHACTR1 mRNA expression in PBMCs.
  9. Associations between PHACTR1 gene polymorphisms and pulse pressure in Chinese Han population.
    Title: Associations between PHACTR1 gene polymorphisms and pulse pressure in Chinese Han population.
  10. silencing PHACTR1 alleviates the nuclear accumulation of p65 and NF-kappaB via interaction with MRTF-A, ensuing attenuating oxidative stress and inflammation in human coronary artery endothelial cells
    Title: PHACTR1 regulates oxidative stress and inflammation to coronary artery endothelial cells via interaction with NF-κB/p65.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 70
MedGen: C4749023 OMIM: 618298 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease.
EBI GWAS Catalog
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
EBI GWAS Catalog
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
EBI GWAS Catalog
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.
EBI GWAS Catalog
Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis.
EBI GWAS Catalog
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
EBI GWAS Catalog
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide linkage and association scans for pulse pressure in Chinese twins.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
EBI GWAS Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1733, MGC126575, MGC126577

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebral cortex development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendrite arborization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatase and actin regulator 1
Names
RPEL repeat containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242648.4 → NP_001229577.1  phosphatase and actin regulator 1 isoform a

    See identical proteins and their annotated locations for NP_001229577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode isoform a.
    Source sequence(s)
    AL008729, AL354680, AL391385, AL591682, Z99495
    Consensus CDS
    CCDS75401.1
    UniProtKB/Swiss-Prot
    A8K1V2, Q3MJ93, Q5JSJ2, Q9C0D0
    UniProtKB/TrEMBL
    A0A8I5KVE0
    Related
    ENSP00000501921.1, ENST00000676159.1
    Conserved Domains (2) summary
    smart00707
    Location:461 → 485
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  2. NM_001322308.3 → NP_001309237.1  phosphatase and actin regulator 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode isoform a.
    Source sequence(s)
    AL008729, AL354680, AL391385, AL591682, Z99495
    Consensus CDS
    CCDS75401.1
    UniProtKB/Swiss-Prot
    A8K1V2, Q3MJ93, Q5JSJ2, Q9C0D0
    UniProtKB/TrEMBL
    A0A8I5KVE0
    Related
    ENSP00000509837.1, ENST00000689548.1
    Conserved Domains (2) summary
    smart00707
    Location:461 → 485
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  3. NM_001322309.3 → NP_001309238.1  phosphatase and actin regulator 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode isoform a.
    Source sequence(s)
    AL008729, AL354680, AL391385, AL591682, Z99495
    Consensus CDS
    CCDS75401.1
    UniProtKB/Swiss-Prot
    A8K1V2, Q3MJ93, Q5JSJ2, Q9C0D0
    UniProtKB/TrEMBL
    A0A8I5KVE0
    Conserved Domains (2) summary
    smart00707
    Location:461 → 485
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  4. NM_001322310.2 → NP_001309239.1  phosphatase and actin regulator 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and includes an additional in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is longer than isoform a.
    Source sequence(s)
    AL008729, AL354680, AL391385, AL591682, Z99495
    UniProtKB/TrEMBL
    A0A8I5KVE0
    Conserved Domains (2) summary
    smart00707
    Location:530 → 554
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  5. NM_001322311.2 → NP_001309240.1  phosphatase and actin regulator 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 6 and 7 encode isoform c.
    Source sequence(s)
    AL008729, AL391385, AL591682
    Consensus CDS
    CCDS93860.1
    UniProtKB/TrEMBL
    A0A6Q8PFA8, A0A8I5KVE0
    Related
    ENSP00000509690.1, ENST00000692995.1
    Conserved Domains (3) summary
    smart00707
    Location:369 → 393
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:48 → 69
    RPEL; RPEL repeat
    cl29414
    Location:330 → 354
    RPEL; RPEL repeat

  6. NM_001322312.3 → NP_001309241.1  phosphatase and actin regulator 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 6 and 7 encode isoform c.
    Source sequence(s)
    AL008729, AL391385, AL591682
    Consensus CDS
    CCDS93860.1
    UniProtKB/TrEMBL
    A0A6Q8PFA8, A0A8I5KVE0
    Related
    ENSP00000502037.1, ENST00000676234.1
    Conserved Domains (3) summary
    smart00707
    Location:369 → 393
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:48 → 69
    RPEL; RPEL repeat
    cl29414
    Location:330 → 354
    RPEL; RPEL repeat

  7. NM_001322313.2 → NP_001309242.1  phosphatase and actin regulator 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also includes an additional in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL008729, AL391385, AL591682
    Consensus CDS
    CCDS93859.1
    UniProtKB/TrEMBL
    A0A8I5KVE0, A0A8I5QJF9
    Related
    ENSP00000509410.1, ENST00000687600.1
    Conserved Domains (3) summary
    smart00707
    Location:438 → 462
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:48 → 69
    RPEL; RPEL repeat
    cl29414
    Location:399 → 423
    RPEL; RPEL repeat

  8. NM_001322314.4 → NP_001309243.1  phosphatase and actin regulator 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation from an alternate start codon, and it also includes an additional in-frame exon in the central coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AL008729, AL391385, AL591682
    Consensus CDS
    CCDS93858.1
    UniProtKB/TrEMBL
    A0A6Q8PGC2
    Related
    ENSP00000502172.2, ENST00000675203.2
    Conserved Domains (2) summary
    smart00707
    Location:531 → 555
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:141 → 162
    RPEL; RPEL repeat

  9. NM_001374581.2 → NP_001361510.1  phosphatase and actin regulator 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL008729, AL354680, AL391385, AL591682, Z99495
    Consensus CDS
    CCDS93857.1
    UniProtKB/TrEMBL
    A0A6Q8PG87, A0A8I5KVE0
    Related
    ENSP00000502157.1, ENST00000674595.1
    Conserved Domains (3) summary
    smart00707
    Location:461 → 485
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat
    cl29414
    Location:422 → 446
    RPEL; RPEL repeat

  10. NM_001374582.1 → NP_001361511.1  phosphatase and actin regulator 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL008729, AL354680, AL391385, AL591682, Z99495
    UniProtKB/TrEMBL
    B4DHU0
    Conserved Domains (2) summary
    smart00707
    Location:491 → 515
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  11. NM_001374583.2 → NP_001361512.1  phosphatase and actin regulator 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL008729, AL391385, AL591682
    UniProtKB/TrEMBL
    A0A8I5KVE0
    Conserved Domains (3) summary
    smart00707
    Location:369 → 393
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:48 → 69
    RPEL; RPEL repeat
    cl29414
    Location:330 → 354
    RPEL; RPEL repeat

  12. NM_001374584.1 → NP_001361513.1  phosphatase and actin regulator 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL354680, Z99495
    Related
    ENST00000690071.1

  13. NM_030948.6 → NP_112210.1  phosphatase and actin regulator 1 isoform a

    See identical proteins and their annotated locations for NP_112210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2, 3 and 4 all encode isoform a.
    Source sequence(s)
    AL008729, AL354680, AL391385, AL591682, Z99495
    Consensus CDS
    CCDS75401.1
    UniProtKB/Swiss-Prot
    A8K1V2, Q3MJ93, Q5JSJ2, Q9C0D0
    UniProtKB/TrEMBL
    A0A8I5KVE0
    Related
    ENSP00000329880.8, ENST00000332995.12
    Conserved Domains (2) summary
    smart00707
    Location:461 → 485
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    12716767..13287837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248934.4 → XP_005248991.1  phosphatase and actin regulator 1 isoform X1

    See identical proteins and their annotated locations for XP_005248991.1

    UniProtKB/TrEMBL
    A0A8I5KVE0
    Conserved Domains (2) summary
    smart00707
    Location:530 → 554
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  2. XM_047418373.1 → XP_047274329.1  phosphatase and actin regulator 1 isoform X1

  3. XM_047418372.1 → XP_047274328.1  phosphatase and actin regulator 1 isoform X1

  4. XM_017010459.3 → XP_016865948.1  phosphatase and actin regulator 1 isoform X3

    UniProtKB/TrEMBL
    A0A6Q8PG87, A0A8I5KVE0
    Conserved Domains (3) summary
    smart00707
    Location:461 → 485
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat
    cl29414
    Location:422 → 446
    RPEL; RPEL repeat

  5. XM_047418374.1 → XP_047274330.1  phosphatase and actin regulator 1 isoform X1

  6. XM_017010464.3 → XP_016865953.1  phosphatase and actin regulator 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5KVE0

  7. XM_047418375.1 → XP_047274331.1  phosphatase and actin regulator 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5QJF9

  8. XM_017010458.3 → XP_016865947.1  phosphatase and actin regulator 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KVE0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    12585196..13161093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354633.1 → XP_054210608.1  phosphatase and actin regulator 1 isoform X1

  2. XM_054354635.1 → XP_054210610.1  phosphatase and actin regulator 1 isoform X1

  3. XM_054354634.1 → XP_054210609.1  phosphatase and actin regulator 1 isoform X1

  4. XM_054354638.1 → XP_054210613.1  phosphatase and actin regulator 1 isoform X3

    UniProtKB/TrEMBL
    A0A6Q8PG87

  5. XM_054354636.1 → XP_054210611.1  phosphatase and actin regulator 1 isoform X1

  6. XM_054354639.1 → XP_054210614.1  phosphatase and actin regulator 1 isoform X4

  7. XM_054354637.1 → XP_054210612.1  phosphatase and actin regulator 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0D0.3 GenPept UniProtKB/Swiss-Prot:Q9C0D0

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