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Trim45 tripartite motif-containing 45 [ Mus musculus (house mouse) ]

Gene ID: 229644, updated on 2-Nov-2024

Summary

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Official Symbol
Trim45provided by MGI
Official Full Name
tripartite motif-containing 45provided by MGI
Primary source
MGI:MGI:1918187
See related
Ensembl:ENSMUSG00000033233 AllianceGenome:MGI:1918187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921530N01Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within bone development. Predicted to be located in cytosol and intercellular bridge. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including axial skeleton; central nervous system; genitourinary system; and sensory organ. Orthologous to human TRIM45 (tripartite motif containing 45). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 4.9), subcutaneous fat pad adult (RPKM 3.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Trim45 in Genome Data Viewer
Location:
3 F2.2; 3 43.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100828516..100844241)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100921203..100936925)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32720 Neighboring gene V-set domain containing T cell activation inhibitor 1 Neighboring gene STARR-positive B cell enhancer ABC_E232 Neighboring gene predicted gene, 40108 Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene STARR-positive B cell enhancer ABC_E2678 Neighboring gene CD101 antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy. Huang X, et al. J Neuroinflammation, 2023 Nov 30. PMID 38037161, Free PMC Article
  2. TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury. Xia Q, et al. Exp Mol Med, 2022 Feb. PMID 35217833, Free PMC Article
  3. E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2. Zhang J, et al. Cell Death Differ, 2023 Apr. PMID 36681779, Free PMC Article
  4. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. Bassett JH, et al. PLoS Genet, 2012. PMID 22876197, Free PMC Article
  5. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy.
    Title: TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy.
  2. TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury.
    Title: TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM45
Names
RING finger protein 99
tripartite motif-containing protein 45
NP_001159424.1
NP_001159425.1
NP_919324.2
XP_011238402.1
XP_030108447.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165952.1 → NP_001159424.1  E3 ubiquitin-protein ligase TRIM45 isoform b

    See identical proteins and their annotated locations for NP_001159424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK150574, AL669872, BY518289
    Consensus CDS
    CCDS17678.1
    UniProtKB/Swiss-Prot
    E9Q2K9, Q3U5H4, Q6PFY8, Q8BVT5
    UniProtKB/TrEMBL
    A2ACL2
    Related
    ENSMUSP00000102593.3, ENSMUST00000106980.9
    Conserved Domains (4) summary
    smart00557
    Location:399 → 497
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00021
    Location:189 → 226
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam00630
    Location:397 → 493
    Filamin; Filamin/ABP280 repeat
    cl23765
    Location:237 → 357
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_001165953.1 → NP_001159425.1  E3 ubiquitin-protein ligase TRIM45 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK076600, AK150574, AL669872, BC057358
    Consensus CDS
    CCDS51018.1
    UniProtKB/Swiss-Prot
    Q6PFY8
    Related
    ENSMUSP00000115669.3, ENSMUST00000134993.3
    Conserved Domains (4) summary
    smart00557
    Location:399 → 497
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00021
    Location:189 → 226
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam00630
    Location:397 → 493
    Filamin; Filamin/ABP280 repeat
    cl23765
    Location:237 → 357
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  3. NM_194343.2 → NP_919324.2  E3 ubiquitin-protein ligase TRIM45 isoform b

    See identical proteins and their annotated locations for NP_919324.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK150574, BC057358
    Consensus CDS
    CCDS17678.1
    UniProtKB/Swiss-Prot
    E9Q2K9, Q3U5H4, Q6PFY8, Q8BVT5
    UniProtKB/TrEMBL
    A2ACL2
    Related
    ENSMUSP00000043389.7, ENSMUST00000037409.13
    Conserved Domains (4) summary
    smart00557
    Location:399 → 497
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00021
    Location:189 → 226
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam00630
    Location:397 → 493
    Filamin; Filamin/ABP280 repeat
    cl23765
    Location:237 → 357
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    100828516..100844241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240100.3 → XP_011238402.1  E3 ubiquitin-protein ligase TRIM45 isoform X1

    Conserved Domains (3) summary
    smart00502
    Location:65 → 185
    BBC; B-Box C-terminal domain
    pfam00630
    Location:225 → 320
    Filamin; Filamin/ABP280 repeat
    cd19785
    Location:16 → 58
    Bbox2_TRIM45_C-X; B-box-type 2 zinc finger found in tripartite motif-containing protein 45 (TRIM45) and similar proteins

  2. XM_030252587.2 → XP_030108447.1  E3 ubiquitin-protein ligase TRIM45 isoform X2

    Conserved Domains (3) summary
    smart00502
    Location:65 → 185
    BBC; B-Box C-terminal domain
    smart00557
    Location:227 → 325
    IG_FLMN; Filamin-type immunoglobulin domains
    cd19785
    Location:16 → 58
    Bbox2_TRIM45_C-X; B-box-type 2 zinc finger found in tripartite motif-containing protein 45 (TRIM45) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFY8.2 GenPept UniProtKB/Swiss-Prot:Q6PFY8

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