Rbm10 RNA binding motif protein 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbm10provided by MGI
Official Full Name: RNA binding motif protein 10provided by MGI
Primary source: MGI:MGI:2384310
See related: Ensembl:ENSMUSG00000031060 AllianceGenome:MGI:2384310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MINAS-60; E430039K10Rik
Summary: Predicted to enable identical protein binding activity; miRNA binding activity; and single-stranded RNA binding activity. Acts upstream of or within negative regulation of RNA metabolic process; negative regulation of vascular associated smooth muscle cell proliferation; and positive regulation of vascular associated smooth muscle cell apoptotic process. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleolus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in TARP syndrome; colorectal cancer; lung adenocarcinoma; and lung cancer. Orthologous to human RBM10 (RNA binding motif protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 28.1), ovary adult (RPKM 27.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.3; X 16.11 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (20483596..20517128)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (20617357..20650889)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBM10 Loss Promotes EGFR-Driven Lung Cancer and Confers Sensitivity to Spliceosome Inhibition.
Title: RBM10 Loss Promotes EGFR-Driven Lung Cancer and Confers Sensitivity to Spliceosome Inhibition.
this study shows that Rbm10 regulates inflammation development via alternative splicing of Dnmt3b
Title: Rbm10 regulates inflammation development via alternative splicing of Dnmt3b.
These results demonstrate a role for RBM10 in the regulation of alternative splicing in two cell models of mouse early development and suggests that mutations in RBM10 could lead to splicing changes that affect normal palate development and cause human disease.
Title: The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development.
Expression of Rbm5 and Rbm10 RNA remained constant during C2C12 myogenesis, but protein levels significantly decreased.
Title: Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.
S1-1 constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner; upon globally reducing RNA polymerase II transcription, S1-1 nuclear bodies enlarge and decrease in number.
Title: S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234099

UniSTS:479219 (e-PCR)
- UniSTS:479219

Rbm10 (e-PCR), detects polymorphism
- UniSTS:479219

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 3'-UTR-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ribosomal large subunit export from nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of vascular associated smooth muscle cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of vascular associated smooth muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of vascular associated smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein 10

Names: Ribosome biogenesis inhibitor MINAS-60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167775.2 → NP_001161247.1 RNA-binding protein 10 isoform 2

See identical proteins and their annotated locations for NP_001161247.1

Status: VALIDATED

Source sequence(s)

AK153736, AL807240

Consensus CDS

CCDS53013.1

UniProtKB/Swiss-Prot

Q99KG3

Related

ENSMUSP00000111033.2, ENSMUST00000115375.8

Conserved Domains (7) summary

smart00547
Location:215 → 239

ZnF_RBZ; Zinc finger domain

COG0724
Location:21 → 232

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12753
Location:127 → 211

RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)

cd12754
Location:298 → 383

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00025
Location:217 → 236

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:563 → 626

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:857 → 901

G-patch; G-patch domain
NM_001167776.2 → NP_001161248.1 RNA-binding protein 10 isoform 3

See identical proteins and their annotated locations for NP_001161248.1

Status: VALIDATED

Source sequence(s)

AK167666, AL672073, AL807240

Consensus CDS

CCDS53014.1

UniProtKB/Swiss-Prot

Q99KG3

Related

ENSMUSP00000111031.2, ENSMUST00000084383.10

Conserved Domains (6) summary

smart00547
Location:138 → 162

ZnF_RBZ; Zinc finger domain

sd00029
Location:140 → 159

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:487 → 550

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:781 → 825

G-patch; G-patch domain

cd12754
Location:221 → 307

RRM2_RBM10; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 10 (RBM10)

cl17169
Location:67 → 134

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001358903.1 → NP_001345832.1 RNA-binding protein 10 isoform 2

Status: VALIDATED

Source sequence(s)

AL672073, AL807240

Consensus CDS

CCDS53013.1

Related

ENSMUSP00000136209.2, ENSMUST00000177738.8

Conserved Domains (7) summary

smart00547
Location:215 → 239

ZnF_RBZ; Zinc finger domain

COG0724
Location:21 → 232

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12753
Location:127 → 211

RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)

cd12754
Location:298 → 383

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00025
Location:217 → 236

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:563 → 626

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:857 → 901

G-patch; G-patch domain
NM_001358904.1 → NP_001345833.1 RNA-binding protein 10 isoform 4

Status: VALIDATED

Source sequence(s)

AL672073, AL807240

Conserved Domains (6) summary

smart00547
Location:138 → 162

ZnF_RBZ; Zinc finger domain

cd12754
Location:221 → 306

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00025
Location:140 → 159

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:486 → 549

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:780 → 824

G-patch; G-patch domain

cl17169
Location:67 → 134

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001358905.1 → NP_001345834.1 RNA-binding protein 10 isoform 5

Status: VALIDATED

Source sequence(s)

AL672073, AL807240

Conserved Domains (6) summary

smart00547
Location:54 → 78

ZnF_RBZ; Zinc finger domain

cd12754
Location:137 → 223

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00025
Location:56 → 75

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:403 → 466

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:697 → 741

G-patch; G-patch domain

cl17169
Location:1 → 50

RRM_SF; RNA recognition motif (RRM) superfamily
NM_145627.3 → NP_663602.1 RNA-binding protein 10 isoform 1

See identical proteins and their annotated locations for NP_663602.1

Status: VALIDATED

Source sequence(s)

AK145991, AL672073, AL807240

Consensus CDS

CCDS40885.1

UniProtKB/Swiss-Prot

Q3TIY0, Q3U5B8, Q3UKI8, Q80U75, Q8BTP8, Q99KG3

Related

ENSMUSP00000111032.2, ENSMUST00000115374.8

Conserved Domains (8) summary

smart00547
Location:215 → 239

ZnF_RBZ; Zinc finger domain

COG0724
Location:21 → 232

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12753
Location:127 → 211

RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)

cd12754
Location:298 → 384

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

TIGR01661
Location:136 → 381

ELAV_HUD_SF; ELAV/HuD family splicing factor

sd00025
Location:217 → 236

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam01585
Location:858 → 902

G-patch; G-patch domain

cd16167
Location:564 → 627

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

20483596..20517128

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251317.1 → XP_030107177.1 RNA-binding protein 10 isoform X3

Conserved Domains (5) summary

smart00547
Location:12 → 36

ZnF_RBZ; Zinc finger domain

cd12754
Location:95 → 181

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00029
Location:14 → 33

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:361 → 424

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:655 → 697

G-patch; G-patch domain
XM_030251316.1 → XP_030107176.1 RNA-binding protein 10 isoform X2

Conserved Domains (6) summary

smart00547
Location:54 → 78

ZnF_RBZ; Zinc finger domain

cd12754
Location:137 → 222

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00029
Location:56 → 75

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:402 → 465

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:696 → 738

G-patch; G-patch domain

cl17169
Location:1 → 50

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006527621.4 → XP_006527684.1 RNA-binding protein 10 isoform X3

Conserved Domains (5) summary

smart00547
Location:12 → 36

ZnF_RBZ; Zinc finger domain

cd12754
Location:95 → 181

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00029
Location:14 → 33

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:361 → 424

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:655 → 697

G-patch; G-patch domain
XM_030251318.1 → XP_030107178.1 RNA-binding protein 10 isoform X3

Conserved Domains (5) summary

smart00547
Location:12 → 36

ZnF_RBZ; Zinc finger domain

cd12754
Location:95 → 181

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00029
Location:14 → 33

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:361 → 424

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:655 → 697

G-patch; G-patch domain
XM_030251319.1 → XP_030107179.1 RNA-binding protein 10 isoform X4

Conserved Domains (5) summary

smart00547
Location:12 → 36

ZnF_RBZ; Zinc finger domain

cd12754
Location:95 → 180

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00029
Location:14 → 33

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:360 → 423

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:654 → 696

G-patch; G-patch domain
XM_030251320.1 → XP_030107180.1 RNA-binding protein 10 isoform X4

Conserved Domains (5) summary

smart00547
Location:12 → 36

ZnF_RBZ; Zinc finger domain

cd12754
Location:95 → 180

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00029
Location:14 → 33

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:360 → 423

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:654 → 696

G-patch; G-patch domain
XM_036161916.1 → XP_036017809.1 RNA-binding protein 10 isoform X1

Related

ENSMUSP00000080738.8, ENSMUST00000082089.14

Conserved Domains (6) summary

smart00547
Location:138 → 162

ZnF_RBZ; Zinc finger domain

sd00029
Location:140 → 159

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:487 → 550

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:781 → 825

G-patch; G-patch domain

cd12754
Location:221 → 307

RRM2_RBM10; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 10 (RBM10)

cl17169
Location:67 → 134

RRM_SF; RNA recognition motif (RRM) superfamily