Map2k5 mitogen-activated protein kinase kinase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map2k5provided by MGI
Official Full Name: mitogen-activated protein kinase kinase 5provided by MGI
Primary source: MGI:MGI:1346345
See related: Ensembl:ENSMUSG00000058444 AllianceGenome:MGI:1346345
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MEK5; Mapkk5; Prkmk5
Summary: Enables MAP kinase kinase activity. Involved in insulin-like growth factor receptor signaling pathway. Acts upstream of or within MAPK cascade and heart development. Located in spindle. Is expressed in early conceptus; oocyte; and telencephalon. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 10.5), thymus adult (RPKM 8.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B- C; 9 33.96 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (63071050..63288964, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (63163768..63381682, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.
Title: MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.
MEK5 promotes lung adenocarcinoma.
Title: MEK5 promotes lung adenocarcinoma.
These results suggest that YAP promotes muscle differentiation by activating the Abl/Src/MEKK3/MEK5/ERK5 kinase cascade.
Title: YAP promotes myogenic differentiation via the MEK5-ERK5 pathway.
MEK5 overexpression inhibits differentiation of osteoblasts.
Title: MEK5 suppresses osteoblastic differentiation.
the MEK5-ERK5 MAP kinase signaling pathway has a critical role in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers
Title: BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The MEK5/ERK5 pathway also mediates FSS-induced Runx-2 expression in osteoblast differentiation.
Title: The MEK5/ERK5 pathway mediates fluid shear stress promoted osteoblast differentiation.
finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression
Title: REST and its downstream molecule Mek5 regulate survival of primordial germ cells.
Transfection of myoblasts with dominant-negative MEK5 blocked the pro-myogenic action of IGF-2.
Title: MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2.
Results show the critical involvement of the MEK5-ERK5 pathway in thymocyte development distinct from that of ERK1/2 and highlight the importance of the MAPK network in mediating differential effects pertaining to T-cell differentiation and apoptosis.
Title: Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis.
MEK5 and big MAP kinase 1 (BMK1) function downstream of MEKK3 in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1
Title: Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:469815 (e-PCR)
- UniSTS:469815

Map2k5 (e-PCR), detects polymorphism
- UniSTS:469815

D9Mit105 (e-PCR), detects polymorphism
- UniSTS:131654

NoName (e-PCR)
- UniSTS:236161

AI324775 (e-PCR)
- UniSTS:159887

AI428457 (e-PCR)
- UniSTS:179917

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERK5 cascade	IEA Inferred from Electronic Annotation more info
involved_in ERK5 cascade	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dual specificity mitogen-activated protein kinase kinase 5

Names: MAP kinase kinase 5; MAPK/ERK kinase 5

NP_001351421.1

EC 2.7.12.2

NP_001351422.1

EC 2.7.12.2

NP_001351423.1

EC 2.7.12.2

NP_035970.1

EC 2.7.12.2

XP_006511209.1

EC 2.7.12.2

XP_011241042.1

EC 2.7.12.2

XP_030100214.1

EC 2.7.12.2

XP_036010824.1

EC 2.7.12.2

XP_036010825.1

EC 2.7.12.2

XP_036010826.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364492.1 → NP_001351421.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC124753

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cl21453
Location:164 → 186

PKc_like; Protein Kinases, catalytic domain
NM_001364493.1 → NP_001351422.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 3

Status: VALIDATED

Source sequence(s)

AC124753, AC160392

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cd06619
Location:164 → 433

PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
NM_001364494.1 → NP_001351423.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 4

Status: VALIDATED

Source sequence(s)

AC124753, AC160392

Conserved Domains (1) summary

cd06619
Location:75 → 353

PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
NM_011840.3 → NP_035970.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 1

See identical proteins and their annotated locations for NP_035970.1

Status: VALIDATED

Source sequence(s)

AC124753, AC160392

Consensus CDS

CCDS23269.1

UniProtKB/Swiss-Prot

Q8CFM3, Q8K360, Q9D222, Q9WVS7

Related

ENSMUSP00000034920.10, ENSMUST00000034920.11

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cd06619
Location:164 → 442

PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

63071050..63288964 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154933.1 → XP_036010826.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X5

Conserved Domains (1) summary

cd06619
Location:4 → 282

PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
XM_006511146.2 → XP_006511209.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X1

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cd06619
Location:164 → 432

PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
XM_036154932.1 → XP_036010825.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X4

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cl21453
Location:164 → 369

PKc_like; Protein Kinases, catalytic domain
XM_036154931.1 → XP_036010824.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X3

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cl21453
Location:164 → 378

PKc_like; Protein Kinases, catalytic domain
XM_030244354.1 → XP_030100214.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X5

Conserved Domains (1) summary

cd06619
Location:4 → 282

PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
XM_011242740.4 → XP_011241042.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X2

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cl21453
Location:164 → 419

PKc_like; Protein Kinases, catalytic domain