Lzts3 leucine zipper, putative tumor suppressor family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lzts3provided by MGI
Official Full Name: leucine zipper, putative tumor suppressor family member 3provided by MGI
Primary source: MGI:MGI:2656976
See related: Ensembl:ENSMUSG00000037703 AllianceGenome:MGI:2656976
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prosapip1
Summary: Predicted to enable PDZ domain binding activity. Predicted to be involved in protein homooligomerization; regulation of dendritic spine morphogenesis; and regulation of postsynapse assembly. Predicted to be located in postsynaptic density. Predicted to be active in dendritic spine and glutamatergic synapse. Is expressed in several structures, including central nervous system; face; limb; metanephros; and sensory organ. Orthologous to human LZTS3 (leucine zipper tumor suppressor family member 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in kidney adult (RPKM 53.5), cortex adult (RPKM 37.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 63.24 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (130474685..130484764, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (130632765..130642866, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggest that Prosapip1 in the NAc is a molecular transducer of structural and synaptic alterations that drive and/or maintain excessive alcohol use.
Title: Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine zipper putative tumor suppressor 3

Names: proSAP-interacting protein 1; proline rich synapse associated protein interacting protein 1 (Prosapip1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291027.1 → NP_001277956.1 leucine zipper putative tumor suppressor 3 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AK148251, AK161711, BY258870, BY630564, BY636255, CO043440

UniProtKB/Swiss-Prot

A2AHG0

Conserved Domains (1) summary

pfam06818
Location:448 → 643

Fez1; Fez1
NM_001291028.1 → NP_001277957.1 leucine zipper putative tumor suppressor 3 isoform c

See identical proteins and their annotated locations for NP_001277957.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.

Source sequence(s)

AK148251, AK161711, BY258870, BY630564, BY636255, CO043440, DN175861

Consensus CDS

CCDS71145.1

UniProtKB/Swiss-Prot

A2AHG0

Conserved Domains (2) summary

COG1196
Location:231 → 426

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:351 → 550

Fez1
NM_197945.4 → NP_922936.3 leucine zipper putative tumor suppressor 3 isoform a

See identical proteins and their annotated locations for NP_922936.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AK148251, AK161711, BY258870, BY630564, BY636255, CO043440

Consensus CDS

CCDS50714.1

UniProtKB/Swiss-Prot

A2AHF9, A2AHG0, Q3TSY0, Q6PE51

Related

ENSMUSP00000037109.7, ENSMUST00000045761.7

Conserved Domains (2) summary

COG1196
Location:346 → 539

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:465 → 664

Fez1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

130474685..130484764 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251156.2 → XP_030107016.1 leucine zipper putative tumor suppressor 3 isoform X3

Related

ENSMUSP00000105889.2, ENSMUST00000110260.8

Conserved Domains (2) summary

COG1196
Location:231 → 426

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:351 → 550

Fez1
XM_017318204.3 → XP_017173693.1 leucine zipper putative tumor suppressor 3 isoform X1

UniProtKB/Swiss-Prot

A2AHF9, A2AHG0, Q3TSY0, Q6PE51

Related

ENSMUSP00000086990.4, ENSMUST00000089561.10

Conserved Domains (2) summary

COG1196
Location:346 → 539

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:465 → 664

Fez1
XM_030251155.2 → XP_030107015.1 leucine zipper putative tumor suppressor 3 isoform X2

Conserved Domains (2) summary

COG1196
Location:328 → 521

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:447 → 646

Fez1
XM_036161971.1 → XP_036017864.1 leucine zipper putative tumor suppressor 3 isoform X4

Conserved Domains (2) summary

TIGR02169
Location:234 → 398

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam06818
Location:334 → 530

Fez1