insra insulin receptor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: insraprovided by ZNC
Official Full Name: insulin receptor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020503-3
See related: Ensembl:ENSDARG00000011948 AllianceGenome:ZFIN:ZDB-GENE-020503-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IRa
Summary: Predicted to enable insulin receptor substrate binding activity and insulin-activated receptor activity. Acts upstream of or within with a positive effect on glycolytic process. Acts upstream of or within with a negative effect on gluconeogenesis. Acts upstream of or within chordate embryonic development and developmental growth. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including fertilized egg; immature eye; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (37544951..37632908, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (37562492..37650960, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insra and Insrb exhibit diversified functions in maintaining glucose homeostasis in zebrafish.
Title: Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect gluconeogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_negative_effect gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein autophosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: insulin receptor a

NP_001136144.1

EC 2.7.10.1

XP_005171317.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142672.1 → NP_001136144.1 insulin receptor a precursor

See identical proteins and their annotated locations for NP_001136144.1

Status: PROVISIONAL

Source sequence(s)

EU447177

UniProtKB/TrEMBL

B7SNG4

Related

ENSDARP00000023951.5, ENSDART00000008302.6

Conserved Domains (6) summary

cd05061
Location:987 → 1274

PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor

cd00063
Location:842 → 921

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:225 → 272

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:170 → 328

Furin-like; Furin-like cysteine rich region

pfam01030
Location:347 → 461

Recep_L_domain; Receptor L domain

pfam07714
Location:994 → 1261

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

37544951..37632908 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171260.5 → XP_005171317.1 insulin receptor a isoform X1

UniProtKB/TrEMBL

A0A8M2BIL6

Conserved Domains (6) summary

cd05061
Location:996 → 1283

PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor

cd00063
Location:851 → 930

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:234 → 281

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:179 → 337

Furin-like; Furin-like cysteine rich region

pfam01030
Location:356 → 470

Recep_L_domain; Receptor L domain

pfam07714
Location:1003 → 1270

Pkinase_Tyr; Protein tyrosine kinase