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Hnf1a HNF1 homeobox A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24817, updated on 2-Nov-2024

Summary

Official Symbol
Hnf1aprovided by RGD
Official Full Name
HNF1 homeobox Aprovided by RGD
Primary source
RGD:3828
See related
EnsemblRapid:ENSRNOG00000001183 AllianceGenome:RGD:3828
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HNF1; Lfb1; Tcf1; LF-B1
Summary
Enables DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and transcription coactivator binding activity. Involved in several processes, including positive regulation of cell communication; regulation of gene expression; and regulation of phosphate metabolic process. Located in chromatin and nucleus. Part of protein-containing complex. Used to study hepatocellular adenoma and hepatocellular carcinoma. Biomarker of extrahepatic cholestasis and kidney disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; glucose metabolism disease (multiple); liver disease (multiple); and renal cell carcinoma. Orthologous to human HNF1A (HNF1 homeobox A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 154.8), Liver (RPKM 66.8) and 1 other tissue See more
Orthologs
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Genomic context

See Hnf1a in Genome Data Viewer
Location:
12q16
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47299171..47333457)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41638536..41672806)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47407811..47433342)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase short chain Neighboring gene signal peptide peptidase like 3 Neighboring gene similar to human chromosome 12 open reading frame 43 Neighboring gene uncharacterized LOC134481304 Neighboring gene 2'-5'-oligoadenylate synthetase-like Neighboring gene uncharacterized LOC120096007 Neighboring gene 2'-5' oligoadenylate synthetase-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in D-glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic nuclear changes IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bile acid and bile salt transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blastocyst development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to L-leucine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to rapamycin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pancreas development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within paraxial mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of NADP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of pronephros size ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in renal D-glucose absorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reproductive structure development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to glucose ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
located_in pronucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hepatocyte nuclear factor 1-alpha
Names
HNF-1-alpha
HNF-1A
LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1
TCF-1
Transcription factor 1, hepatic
albumin proximal factor
hepatic nuclear factor 1
hepatic nuclear factor-1-alpha
liver-specific transcription factor LF-B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012669.1NP_036801.1  hepatocyte nuclear factor 1-alpha

    See identical proteins and their annotated locations for NP_036801.1

    Status: PROVISIONAL

    Source sequence(s)
    J03170
    UniProtKB/Swiss-Prot
    P15257
    UniProtKB/TrEMBL
    A6J1X4
    Related
    ENSRNOP00000001565.2, ENSRNOT00000001565.5
    Conserved Domains (4) summary
    cd00086
    Location:200273
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:282538
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
    pfam04813
    Location:540627
    HNF-1A_C; Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
    pfam04814
    Location:8167
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    47299171..47333457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089095.2XP_038945023.1  hepatocyte nuclear factor 1-alpha isoform X1

    Conserved Domains (4) summary
    cd00086
    Location:93166
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:175431
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04813
    Location:433520
    HNF-1A_C; Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C-terminus
    pfam04814
    Location:161
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus