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carB carbamoyl-phosphate synthase large subunit [ Candidatus Methanoplasma termitum ]

Gene ID: 24817931, updated on 22-Oct-2024

Summary

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Gene symbol
carB
Gene description
carbamoyl-phosphate synthase large subunit
Locus tag
Mpt1_RS01285
Gene type
protein coding
Organism
Candidatus Methanoplasma termitum (strain: MpT1)
Lineage
Archaea; Methanobacteriati; Thermoplasmatota; Thermoplasmata; Methanomassiliicoccales; Methanomassiliicoccaceae; Candidatus Methanoplasma
Old locus tag
Mpt1_c02580
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Genomic context

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NZ_CP010070.1Genomic Context describing neighboring genes Neighboring gene homocitrate synthase Neighboring gene mRNA surveillance protein pelota Neighboring gene glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit Neighboring gene hypothetical protein Neighboring gene peptidyl-tRNA hydrolase Pth2

Genomic regions, transcripts, and products

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Genomic Sequence:
NZ_CP010070.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective inactivation of the glutamine binding site of Escherichia coli carbamyl phosphate synthetase by 2-amino-4-oxo-5-chloropentanoic acid. Khedouri E, et al. Biochemistry, 1966 Nov. PMID 5339592
  2. Reversible dissociation of the monomer of glutamine-dependent carbamyl phosphate synthetase into catalytically active heavy and light subunits. Trotta PP, et al. J Biol Chem, 1974 Jan 25. PMID 4358555
  3. Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin. Miles BW, et al. J Biol Chem, 2002 Feb 8. PMID 11729189
  4. Long-range allosteric transitions in carbamoyl phosphate synthetase. Thoden JB, et al. Protein Sci, 2004 Sep. PMID 15322282, Free PMC Article
  5. The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution. Thoden JB, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jan. PMID 10089390

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
carbamoyl-phosphate synthase large subunit
WP_048111509.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NZ_CP010070.1 Reference assembly

    Range
    276666..279872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_048111509.1 carbamoyl-phosphate synthase large subunit [Candidatus Methanoplasma termitum]

    See identical proteins and their annotated locations for WP_048111509.1

    UniProtKB/TrEMBL
    A0A0A7LAZ0
    Conserved Domains (5) summary
    PRK05294
    Location:1 → 1066
    carB; carbamoyl phosphate synthase large subunit; Reviewed
    cd01424
    Location:936 → 1046
    MGS_CPS_II; Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways ...
    pfam02786
    Location:126 → 331
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    pfam02787
    Location:422 → 536
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:667 → 867
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
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