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Tnnt3 troponin T3, fast skeletal type [ Rattus norvegicus (Norway rat) ]

Gene ID: 24838, updated on 14-Nov-2024

Summary

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Official Symbol
Tnnt3provided by RGD
Official Full Name
troponin T3, fast skeletal typeprovided by RGD
Primary source
RGD:3883
See related
EnsemblRapid:ENSRNOG00000020332 AllianceGenome:RGD:3883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tnt
Summary
Predicted to enable calcium-dependent protein binding activity and cytoskeletal protein binding activity. Predicted to contribute to actin binding activity. Involved in regulation of striated muscle contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 56590.8) See more
Orthologs
human mouse all
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Genomic context

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See Tnnt3 in Genome Data Viewer
Location:
1q41
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (207082014..207099014)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197652535..197669736)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (215666628..215683628)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene troponin I2, fast skeletal type Neighboring gene synaptotagmin 8 Neighboring gene lymphocyte-specific protein 1 Neighboring gene proline rich 33 Neighboring gene uncharacterized LOC102548505 Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene microRNA 675 Neighboring gene H19 imprinted maternally expressed transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Time-dependent changes in expression of troponin subunit isoforms in unloaded rat soleus muscle. Stevens L, et al. Am J Physiol Cell Physiol, 2002 May. PMID 11940518
  2. [Doppler ultrasound in monitoring twin pregnancies with early discordant growth]. Behrens O, et al. Z Geburtshilfe Perinatol, 1992 Sep-Oct. PMID 1299083
  3. Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene. Breitbart RE, et al. Cell, 1985 May. PMID 2986851
  4. Complete nucleotide sequence of the fast skeletal troponin T gene. Alternatively spliced exons exhibit unusual interspecies divergence. Breitbart RE, et al. J Mol Biol, 1986 Apr 5. PMID 3735424
  5. Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats. Schilder RJ, et al. J Exp Biol, 2011 May 1. PMID 21490260, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Weight-dependent quantitative variation in Tnnt3 alternative splicing appears to be an evolutionarily conserved feature of skeletal muscle.
    Title: Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats.
  2. HU induced profound slow-to-fast isoform transitions of all Tn subunits, although to different extents and with different time courses. This suggests that slow and fast counterparts of Tn subunit isoforms are regulated independently in response to HU.
    Title: Time-dependent changes in expression of troponin subunit isoforms in unloaded rat soleus muscle.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to actin binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tropomyosin binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to tropomyosin binding ISO
Inferred from Sequence Orthology
more info
  
enables tropomyosin binding ISO
Inferred from Sequence Orthology
more info
  
enables troponin C binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables troponin C binding IEA
Inferred from Electronic Annotation
more info
  
enables troponin C binding ISO
Inferred from Sequence Orthology
more info
  
enables troponin I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables troponin I binding IEA
Inferred from Electronic Annotation
more info
  
enables troponin I binding ISO
Inferred from Sequence Orthology
more info
  
enables troponin T binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of calcium-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of striated muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of striated muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
  
part_of troponin complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
troponin T, fast skeletal muscle
Names
fTnT
fast skeletal muscle troponin T
tnTf
troponin T type 3 (skeletal, fast)
troponin T3, skeletal, fast

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270664.1 → NP_001257593.1  troponin T, fast skeletal muscle isoform 11

    See identical proteins and their annotated locations for NP_001257593.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (11) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY62
    Conserved Domains (1) summary
    pfam00992
    Location:52 → 188
    Troponin

  2. NM_001270665.1 → NP_001257594.1  troponin T, fast skeletal muscle isoform 1

    See identical proteins and their annotated locations for NP_001257594.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 represent the longest transcripts and encode the longest isoforms (1 and 2).
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P09739, P09740, Q304F4, Q4PPA0
    UniProtKB/TrEMBL
    A6HY59, A6HY62
    Conserved Domains (1) summary
    pfam00992
    Location:63 → 199
    Troponin

  3. NM_001270666.1 → NP_001257595.1  troponin T, fast skeletal muscle isoform 2

    See identical proteins and their annotated locations for NP_001257595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) and variant 1 represent the longest transcripts and encode the longest isoforms (2 and 1).
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY61
    Related
    ENSRNOP00000062891.5, ENSRNOT00000063918.6
    Conserved Domains (1) summary
    pfam00992
    Location:63 → 199
    Troponin

  4. NM_001270668.1 → NP_001257597.1  troponin T, fast skeletal muscle isoform 3

    See identical proteins and their annotated locations for NP_001257597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY61
    Conserved Domains (1) summary
    pfam00992
    Location:52 → 188
    Troponin

  5. NM_001270670.1 → NP_001257599.1  troponin T, fast skeletal muscle isoform 4

    See identical proteins and their annotated locations for NP_001257599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY61
    Conserved Domains (1) summary
    pfam00992
    Location:57 → 193
    Troponin

  6. NM_001270671.1 → NP_001257600.1  troponin T, fast skeletal muscle isoform 5

    See identical proteins and their annotated locations for NP_001257600.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY62
    Related
    ENSRNOP00000062653.4, ENSRNOT00000066135.5
    Conserved Domains (1) summary
    pfam00992
    Location:57 → 193
    Troponin

  7. NM_001270672.1 → NP_001257601.1  troponin T, fast skeletal muscle isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY62
    Conserved Domains (1) summary
    pfam00992
    Location:54 → 190
    Troponin

  8. NM_001270673.1 → NP_001257602.1  troponin T, fast skeletal muscle isoform 7

    See identical proteins and their annotated locations for NP_001257602.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY62
    Related
    ENSRNOP00000059829.2, ENSRNOT00000066896.6
    Conserved Domains (1) summary
    pfam00992
    Location:58 → 194
    Troponin

  9. NM_001270675.1 → NP_001257604.1  troponin T, fast skeletal muscle isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two alternate in-frame exons and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY61
    Conserved Domains (1) summary
    pfam00992
    Location:54 → 190
    Troponin

  10. NM_001270676.1 → NP_001257605.1  troponin T, fast skeletal muscle isoform 10

    See identical proteins and their annotated locations for NP_001257605.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an alternate in-frame exon and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY61
    Conserved Domains (1) summary
    pfam00992
    Location:58 → 194
    Troponin

  11. NM_001270677.1 → NP_001257606.1  troponin T, fast skeletal muscle isoform 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (12) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY62
    Conserved Domains (1) summary
    pfam00992
    Location:48 → 183
    Troponin; Troponin

  12. NM_001270678.1 → NP_001257607.1  troponin T, fast skeletal muscle isoform 13

    See identical proteins and their annotated locations for NP_001257607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) lacks an alternate in-frame exon and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (13) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY61
    Conserved Domains (1) summary
    pfam00992
    Location:59 → 195
    Troponin

  13. NM_031532.2 → NP_113720.1  troponin T, fast skeletal muscle isoform 8

    See identical proteins and their annotated locations for NP_113720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CB612473, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HY60, A6HY62
    Conserved Domains (1) summary
    pfam00992
    Location:59 → 195
    Troponin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    207082014..207099014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281060.1 → XP_063137130.1  troponin T, fast skeletal muscle isoform X1

  2. XM_063281062.1 → XP_063137132.1  troponin T, fast skeletal muscle isoform X3

    Related
    ENSRNOP00000049386.4, ENSRNOT00000040598.7

  3. XM_063281061.1 → XP_063137131.1  troponin T, fast skeletal muscle isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHY9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09739.2 GenPept UniProtKB/Swiss-Prot:P09739

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
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