Lipa lipase A, lysosomal acid type [ Rattus norvegicus (Norway rat) ]

Gene ID: 25055, updated on 2-Nov-2024

Summary

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Official Symbol: Lipaprovided by RGD
Official Full Name: lipase A, lysosomal acid typeprovided by RGD
Primary source: RGD:3008
See related: EnsemblRapid:ENSRNOG00000019077 AllianceGenome:RGD:3008
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LAL; Lip1; Chole; Chole2
Summary: Enables sterol ester esterase activity. Involved in fatty acid metabolic process and sterol metabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in Wolman disease and cholesterol ester storage disease. Orthologous to human LIPA (lipase A, lysosomal acid type). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1233.2), Adrenal (RPKM 881.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Lipa in Genome Data Viewer

Location:: 1q53

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (241437524..241470936, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (232024351..232057735, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (252816536..252959348, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH135375 (e-PCR)
- UniSTS:218652

RH142813 (e-PCR)
- UniSTS:232060

d3mgh25 (e-PCR)
- UniSTS:121784

D3Wox13 (e-PCR)
- UniSTS:117967

RH139563 (e-PCR)
- UniSTS:221648

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipase activity	ISO Inferred from Sequence Orthology more info
enables sterol ester esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol ester esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol ester esterase activity	IEA Inferred from Electronic Annotation more info
enables sterol ester esterase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in T cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in acute inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in adaptive thermogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adaptive thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood vessel endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in bone marrow development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone marrow development	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation in bone marrow	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell proliferation in bone marrow	ISO Inferred from Sequence Orthology more info
involved_in cellular lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol efflux	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol storage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol storage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in common myeloid progenitor cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within common myeloid progenitor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in defecation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defecation	ISO Inferred from Sequence Orthology more info
involved_in determination of adult lifespan	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in fat cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid import into cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid import into cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid storage	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipoprotein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in liver morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in macrophage homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macrophage homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level chemical homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level chemical homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level homeostasis	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutral lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in respiratory burst involved in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory burst involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in response to cold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
involved_in response to dietary excess	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipid	ISO Inferred from Sequence Orthology more info
involved_in response to rapamycin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to rapamycin	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin A	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to vitamin A	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in spleen development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sterol metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tissue remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue remodeling	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride-rich lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride-rich lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in vitamin A metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vitamin A metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosomal acid lipase/cholesteryl ester hydrolase

Names: Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25; acid cholesteryl ester hydrolase; cholesteryl esterase; diacylglycerol lipase; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase 1; lysosomal acid lipase A; pancreatic cholesterol esterase; sterol esterase; triacylglycerol ester hydrolase; triacylglycerol lipase

NP_036864.3

EC 3.1.1.13

XP_006231337.1

EC 3.1.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012732.3 → NP_036864.3 lysosomal acid lipase/cholesteryl ester hydrolase precursor

See identical proteins and their annotated locations for NP_036864.3

Status: PROVISIONAL

Source sequence(s)

BC072532

UniProtKB/Swiss-Prot

Q64194

UniProtKB/TrEMBL

A0A0G2K7Y6, Q6IMY6

Related

ENSRNOP00000074398.1, ENSRNOT00000078279.3

Conserved Domains (3) summary

PLN02872
Location:7 → 394

PLN02872; triacylglycerol lipase

pfam04083
Location:35 → 96

Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

pfam12695
Location:78 → 203

Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

241437524..241470936 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231275.5 → XP_006231337.1 lysosomal acid lipase/cholesteryl ester hydrolase isoform X1

See identical proteins and their annotated locations for XP_006231337.1

UniProtKB/Swiss-Prot

Q64194

UniProtKB/TrEMBL

A0A0G2K7Y6, Q6IMY6

Conserved Domains (3) summary

PLN02872
Location:7 → 394

PLN02872; triacylglycerol lipase

pfam04083
Location:35 → 96

Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

pfam12695
Location:78 → 203

Abhydrolase_5; Alpha/beta hydrolase family