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rad3 ATR checkpoint kinase Rad3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540719, updated on 18-Sep-2024

Summary

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Official Symbol
rad3
Official Full Name
ATR checkpoint kinase Rad3
Primary source
PomBase:SPBC216.05
Locus tag
SPOM_SPBC216.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rad3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (904184..913629)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene peptide-methionine (R)-S-oxide reductase Mxr2 Neighboring gene replication fork protection complex subunit Swi1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TORC1 serine/threonine protein kinase Tor2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Requirement of sequences outside the conserved kinase domain of fission yeast Rad3p for checkpoint control. Chapman CR, et al. Mol Biol Cell, 1999 Oct. PMID 10512862, Free PMC Article
  2. RecQ DNA Helicase Rqh1 Promotes Rad3(ATR) Kinase Signaling in the DNA Replication Checkpoint Pathway of Fission Yeast. Ahamad N, et al. Mol Cell Biol, 2020 Aug 14. PMID 32541066, Free PMC Article
  3. The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Jimenez G, et al. Proc Natl Acad Sci U S A, 1992 Jun 1. PMID 1594599, Free PMC Article
  4. Checkpoint effects and telomere amplification during DNA re-replication in fission yeast. Mickle KL, et al. BMC Mol Biol, 2007 Dec 21. PMID 18154680, Free PMC Article
  5. Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. Lopez-Girona A, et al. Proc Natl Acad Sci U S A, 2001 Sep 25. PMID 11553781, Free PMC Article

See all (157) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RecQ DNA Helicase Rqh1 Promotes Rad3(ATR) Kinase Signaling in the DNA Replication Checkpoint Pathway of Fission Yeast.
    Title: RecQ DNA Helicase Rqh1 Promotes Rad3(ATR) Kinase Signaling in the DNA Replication Checkpoint Pathway of Fission Yeast.
  2. RAD3 signaling plays a role in the DNA replication and telomere shortening.
    Title: A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3(ATR) Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast.
  3. It is a DNA damage sensor kinases and plays a roll in telomere maintenance.
    Title: [Telomere maintenance by DNA damage sensor kinases, ATM and ATR].
  4. fission yeast shelterin maintains telomere length homeostasis by coordinating the differential arrival of leading (Polepsilon) and lagging (Polalpha) strand DNA polymerases at telomeres to modulate Rad3(ATR) association
    Title: Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.
  5. Tel1(ATM)/Rad3(ATR)-dependent Ccq1 Thr93 phosphorylation is a critical regulator of telomere maintenance in fission yeast.
    Title: Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.
  6. Rad3 phosphorylates histone H2A to mobilize Brc1 to critical genomic domains during S-phase, and this pathway functions in parallel with Rqh1 DNA helicase in maintaining genome integrity.
    Title: Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.
  7. The N-terminus of Nbs1 contributes to the recruitment of Rad3(ATR)-Rad26(ATRIP) to telomeres.
    Title: A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.
  8. Tel1 and Rad3 are required for both protection of telomeres against recombination and promotion of telomerase recruitment.
    Title: Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment.
  9. DNA-damage checkpoint pathways mediated by Cds1 and Rad3.
    Title: Checkpoint effects and telomere amplification during DNA re-replication in fission yeast.
  10. An elevated level of Cdc18 activates the Rad3-dependent checkpoint either directly or indirectly.
    Title: Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic G2/MI DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic recombination checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of initiation of premeiotic DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to chromosome, telomeric region IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ATR-ATRIP complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATR checkpoint kinase Rad3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    904184..913629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021264.3 → NP_595357.1  ATR checkpoint kinase Rad3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595357.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q02099, Q92391, Q9UUM1
    Conserved Domains (4) summary
    smart00802
    Location:862 → 968
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    COG5032
    Location:177 → 2386
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd00892
    Location:2051 → 2322
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
    pfam02260
    Location:2355 → 2386
    FATC; FATC domain
Nucleotide Protein
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