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fft3 protein Fft3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541531, updated on 18-Sep-2024

Summary

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Official Symbol
fft3
Official Full Name
protein Fft3
Primary source
PomBase:SPAC25A8.01c
Locus tag
SPOM_SPAC25A8.01C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
snf2SR
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Genomic context

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See fft3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2098195..2101805, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Atg14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Mis6 inner kinetochore subcomplex maintains CENP-A nucleosomes against centromeric non-coding transcription during mitosis. Hirai H, et al. Commun Biol, 2022 Aug 15. PMID 35970865, Free PMC Article
  2. Chromatin remodeler Fft3 plays a dual role at blocked DNA replication forks. Ait-Saada A, et al. Life Sci Alliance, 2019 Oct. PMID 31575705, Free PMC Article
  3. It's fun to transcribe with Fun30: A model for nucleosome dynamics during RNA polymerase II-mediated elongation. Lee J, et al. Transcription, 2018. PMID 28925811, Free PMC Article
  4. The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation. Strålfors A, et al. PLoS Genet, 2011 Mar. PMID 21437270, Free PMC Article
  5. Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities. Ohba T, et al. Genes Cells, 2008 Jun. PMID 18422602

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results found that Fft3 is important for DNA repair and is needed for single-strand annealing of an induced double-strand break. Furthermore, an inducible replication fork barrier system shows that Fft3 has two distinct roles at blocked DNA replication forks. First, Fft3 is needed for the resection of nascent strands, and second, it is required to restart the blocked forks independently of its ATPase activity.
    Title: Chromatin remodeler Fft3 plays a dual role at blocked DNA replication forks.
  2. Data indicate Fun30(Fft3) as a chromatin remodeller, which localizes at transcribing regions to promote RNA polymerase II (RNAPII) transcription.
    Title: Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation.
  3. These analyses of the regulation of nucleosome dynamics by Fun30(Fft3) during RNA polymerase II (RNAPII) -mediated transcription reveal an unprecedented role for a chromatin remodeler in nucleosome disassembly at transcribing regions. They offer a new conceptual framework that can describe, in mathematical terms, how nucleosome dynamics are controlled during RNAPII-mediated elongation.
    Title: It's fun to transcribe with Fun30: A model for nucleosome dynamics during RNA polymerase II-mediated elongation.
  4. This work uncovers a conserved factor critical for epigenetic inheritance of heterochromatin and describes a mechanism in which Fft3 suppresses nucleosome turnover, preventing formation of structural barriers that impede replication at fragile regions in the genome.
    Title: SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication.
  5. We propose that Fft3 has a global role in mediating association between specific chromatin domains and the nuclear envelope
    Title: The Fun30 chromatin remodeler Fft3 controls nuclear organization and chromatin structure of insulators and subtelomeres in fission yeast.
  6. Fft3 controls the identity of chromatin domains by protecting these regions from euchromatin assembly.
    Title: The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation.
  7. Results indicate that Snf2SR is involved in the Ran GTPase cycle in vivo.
    Title: Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity EXP
Inferred from Experiment
more info
 PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding EXP
Inferred from Experiment
more info
 PubMed 
enables histone chaperone activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables nucleosome array spacer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA double-strand break processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair-dependent chromatin remodeling EXP
Inferred from Experiment
more info
 PubMed 
involved_in attachment of telomeric heterochromatin to nuclear envelope IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing EXP
Inferred from Experiment
more info
 PubMed 
involved_in transcription elongation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein Fft3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2098195..2101805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019048.3 → NP_593617.1  protein Fft3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593617.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O42861, Q9US92
    Conserved Domains (3) summary
    cd00046
    Location:408 → 549
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:390 → 695
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:762 → 874
    Helicase_C; Helicase conserved C-terminal domain
Nucleotide Protein
Heading Accession and Version

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