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ura1 bifunctional carbamoyl-phosphate synthase/aspartate carbamoyltransferase Ura1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541544, updated on 18-Sep-2024

Summary

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Official Symbol
ura1
Official Full Name
bifunctional carbamoyl-phosphate synthase/aspartate carbamoyltransferase Ura1
Primary source
PomBase:SPAC22G7.06c
Locus tag
SPOM_SPAC22G7.06C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ura1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (739167..746114, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene poly(A)-specific ribonuclease complex subunit Pan2 Neighboring gene ncRNA Neighboring gene krr family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloned ural locus of Schizosaccharomyces pombe propagates autonomously in this yeast assuming a polymeric form. Sakaguchi J, et al. Proc Natl Acad Sci U S A, 1982 Dec. PMID 6961452, Free PMC Article
  2. Polypeptone induces dramatic cell lysis in ura4 deletion mutants of fission yeast. Matsuo Y, et al. PLoS One, 2013. PMID 23555823, Free PMC Article
  3. Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle. Benko Z, et al. Curr Genet, 1997 Jun. PMID 9211790
  4. Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4. Anderson HE, et al. PLoS One, 2010 Oct 18. PMID 20976105, Free PMC Article
  5. A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast. Mathiassen SG, et al. J Biol Chem, 2015 Aug 21. PMID 26152728, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GMP synthase (glutamine-hydrolyzing) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
  
enables aspartate carbamoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartate carbamoyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables aspartate carbamoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carbamoyl-phosphate synthase (ammonia) activity IEA
Inferred from Electronic Annotation
more info
  
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT enables dihydroorotase activity EXP
Inferred from Experiment
more info
 PubMed 
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glutamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bifunctional carbamoyl-phosphate synthase/aspartate carbamoyltransferase Ura1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    739167..746114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018453.3 → NP_593055.1  bifunctional carbamoyl-phosphate synthase/aspartate carbamoyltransferase Ura1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593055.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09794
    Conserved Domains (12) summary
    cd01744
    Location:265 → 440
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    COG0505
    Location:57 → 449
    CarA; Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism, Nucleotide transport and metabolism]
    COG0540
    Location:1931 → 2242
    PyrB; Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]
    cd01316
    Location:1535 → 1862
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    cd01423
    Location:1395 → 1515
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01369
    Location:473 → 1517
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam00185
    Location:2085 → 2234
    OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
    pfam00988
    Location:61 → 197
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    pfam02729
    Location:1938 → 2078
    OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
    pfam02786
    Location:593 → 795
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    pfam02787
    Location:882 → 1002
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:1151 → 1328
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
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