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cut9 anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541592, updated on 22-Jun-2024

Summary

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Gene symbol
cut9
Gene description
anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6
Locus tag
SPOM_SPAC6F12.15C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
apc6; dre1
Old locus tag
SPAC6F12.15c
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Genomic context

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See cut9 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (1342057..1344785, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene geranyltranstransferase Fps1 Neighboring gene anaphase-promoting complex TPR lobe subcomplex subunit Apc8 Neighboring gene ncRNA Neighboring gene TRAMP complex ATP-dependent RNA helicase subunit Mtr4 Neighboring gene ncRNA Neighboring gene cleavage and polyadenylation specificity factor complex subunit Rna14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27. Zhang Z, et al. EMBO J, 2010 Nov 3. PMID 20924356, Free PMC Article
  2. Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis. Tatebayashi K, et al. Genetics, 1998 Jan. PMID 9475720, Free PMC Article
  3. Cut2 proteolysis required for sister-chromatid seperation in fission yeast. Funabiki H, et al. Nature, 1996 May 30. PMID 8632802
  4. APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation. Blanco MA, et al. EMBO J, 2000 Aug 1. PMID 10921876, Free PMC Article
  5. The role of the destruction box and its neighbouring lysine residues in cyclin B for anaphase ubiquitin-dependent proteolysis in fission yeast: defining the D-box receptor. Yamano H, et al. EMBO J, 1998 Oct 1. PMID 9755167, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
part_of pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1342057..1344785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018731.3 → NP_593301.1  anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593301.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14231, P41889
    Conserved Domains (5) summary
    sd00006
    Location:475 → 503
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:516 → 545
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:96 → 176
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13181
    Location:200 → 232
    TPR_8; Tetratricopeptide repeat
    pfam13414
    Location:516 → 581
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2103262A.1

Gene LinkOut

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