rng2 IQ motif containing GTPase activating protein [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Gene symbol: rng2
Gene description: IQ motif containing GTPase activating protein
Locus tag: SPOM_SPAC4F8.13C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Old locus tag: SPAC4F8.13c
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Genomic context

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See rng2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (2645428..2650427)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell cycle-dependent phosphorylation of IQGAP is involved in assembly and stability of the contractile ring in fission yeast.
Title: Cell cycle-dependent phosphorylation of IQGAP is involved in assembly and stability of the contractile ring in fission yeast.
Data indicate several distinct functions of Rng2 at multiple stages of cytokinesis.
Title: Separate roles of IQGAP Rng2p in forming and constricting the Schizosaccharomyces pombe cytokinetic contractile ring.
Mid1p recruits Rng2p to cortical nodes at the cell-division site and Rng2p, in turn, recruits other components of the actomyosin ring to cortical nodes, thereby ensuring correct placement of the division site.
Title: IQGAP-related Rng2p organizes cortical nodes and ensures position of cell division in fission yeast.
Findings indicate that Rng2 is involved in the generation of CR F-actin and simultaneously bundles the filaments and regulates its dynamics by counteracting the effects of Adf1.
Title: Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring.
The IQGAP-related Rng2 protein is a component of the actomyosin ring and spindle pole body, and is required for actomyosin ring construction following assembly of F-actin at the division site.
Title: Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.
The 2.21 angstrom resolution crystal structure of the amino-terminal 190 amino acids of Rng2, including the calponin-homology domain and 40 residues that do not share sequence similarity with known proteins. [Rng2]
Title: Structure, crystal packing and molecular dynamics of the calponin-homology domain of Schizosaccharomyces pombe Rng2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal anchor activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actomyosin contractile ring assembly actin filament bundle convergence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic actomyosin contractile ring assembly	EXP Inferred from Experiment more info	PubMed
involved_in mitotic actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic actomyosin contractile ring assembly actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic actomyosin contractile ring contraction	EXP Inferred from Experiment more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in medial cortical node	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic actomyosin contractile ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic actomyosin contractile ring, proximal layer	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: IQ motif containing GTPase activating protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

2645428..2650427

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001019289.3 → NP_593860.1 IQ motif containing GTPase activating protein [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593860.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O14188, Q9USG0

Conserved Domains (4) summary

cd12206
Location:846 → 1217

RasGAP_IQGAP_related; Ras-GTPase Activating Domain of proteins related to IQGAPs

COG5261
Location:1 → 1489

IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

cd00014
Location:42 → 145

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam03836
Location:1274 → 1410

RasGAP_C; RasGAP C-terminus