has2 hyaluronan synthase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: has2provided by ZNC
Official Full Name: hyaluronan synthase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-020828-1
See related: Ensembl:ENSDARG00000036987 AllianceGenome:ZFIN:ZDB-GENE-020828-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: DG42
Summary: Predicted to enable hyaluronan synthase activity. Acts upstream of or within several processes, including circulatory system development; dorsal convergence; and fin regeneration. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; mesoderm; pericardial region; presumptive paraxial mesoderm; and swim bladder bud. Orthologous to human HAS2 (hyaluronan synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (15371419..15387459, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (15481299..15497339, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fgf signaling is required early, from 6 to 10h pf,for has2 activation. Loss of has2 results inthe loss of the chondrogenic program resulting in postchordal neurocranial defects in Fgf loss-of-function embryos. Shh is not essential for this early activation of has2.
Title: An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull.
propose here a rather unique role of Med10 in orchestrating cardiac valve formation by mediating Foxn4 dependent tbx2b transcription, expression of Has2 and subsequently proper development of the cardiac jelly
Title: The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation.
identify Npnt as a novel upstream regulator of Bmp4-Has2 signaling that plays a crucial role in AV canal differentiation
Title: Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish.
MiR-23 is both necessary and sufficient for restricting the number of endocardial cells that differentiate into endocardial cushion cells by inhibiting Has2 and extracellular hyaluronic acid production.
Title: MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production.
data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5, tbx20, and has2 in the hear
Title: Elevated glucose induces congenital heart defects by altering the expression of tbx5, tbx20, and has2 in developing zebrafish embryos.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hyaluronan synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronan synthase activity	IEA Inferred from Electronic Annotation more info
enables hyaluronan synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular canal development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within atrioventricular valve development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell migration in hindbrain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal convergence	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular polysaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart jogging	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart looping	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaluronan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hyaluronan biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hyaluronan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in hyaluronan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of urine volume	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal water absorption	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hyaluronan synthase 2

NP_705936.1

EC 2.4.1.212

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153650.2 → NP_705936.1 hyaluronan synthase 2

See identical proteins and their annotated locations for NP_705936.1

Status: PROVISIONAL

Source sequence(s)

BC100130

UniProtKB/TrEMBL

F6NV82, Q498P4, Q9DG41

Related

ENSDARP00000053753.5, ENSDART00000053754.7

Conserved Domains (3) summary

cd06434
Location:84 → 361

GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

TIGR04242
Location:34 → 463

nodulat_NodC; chitooligosaccharide synthase NodC

cl01224
Location:399 → 493

DUF805; Protein of unknown function (DUF805)