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TIMM10 translocase of inner mitochondrial membrane 10 [ Homo sapiens (human) ]

Gene ID: 26519, updated on 5-Mar-2024

Summary

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Official Symbol
TIMM10provided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 10provided by HGNC
Primary source
HGNC:HGNC:11814
See related
Ensembl:ENSG00000134809 MIM:602251; AllianceGenome:HGNC:11814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIM10; TIM10A; TIMM10A
Summary
The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in kidney (RPKM 18.4), liver (RPKM 14.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q12.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57528464..57530754, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57478642..57492843, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57295937..57298227, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:57256964-57257464 Neighboring gene solute carrier family 43 member 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:57260708-57261907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57267535-57268310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57268311-57269084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4719 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:57293175-57293772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4720 Neighboring gene RNA, 7SL, cytoplasmic 605, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57310876-57311766 Neighboring gene smoothelin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4723 Neighboring gene ubiquitin conjugating enzyme E2 L6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3351

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays. Carey KA, et al. Pathol Int, 2006 May. PMID 16669873
  2. Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. Allen S, et al. J Biol Chem, 2003 Oct 3. PMID 12882976
  3. Assembly of Tim9 and Tim10 into a functional chaperone. Vial S, et al. J Biol Chem, 2002 Sep 27. PMID 12138093
  4. Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Koehler CM, et al. Science, 1998 Jan 16. PMID 9430585
  5. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. Rothbauer U, et al. J Biol Chem, 2001 Oct 5. PMID 11489896

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  2. The crystal structure of TIM9.10 described here reveals a previously undescribed alpha-propeller topology in which helical "blades" radiate from a narrow central pore lined with polar residues.
    Title: Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller.
  3. Marked differences in the expression of PTMA and Tim10 were observed during the differentiation of human primary skeletal muscle cells.
    Title: Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays.
  4. in contrast to yeast, only a small fraction of Tim9-Tim10a-Tim10b complex is in a stable association with Tim22
    Title: Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human translocase of inner mitochondrial membrane 10 homolog (yeast) (TIMM10) at amino acid residues 72-73 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables membrane insertase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein insertion into mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein insertion into mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein targeting to mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
involved_in sensory perception of sound TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of TIM23 mitochondrial import inner membrane translocase complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial intermembrane space TAS
Traceable Author Statement
more info
 PubMed 
part_of mitochondrial intermembrane space protein transporter complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial intermembrane space protein transporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim10
Names
translocase of inner mitochondrial membrane 10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012456.3 → NP_036588.1  mitochondrial import inner membrane translocase subunit Tim10

    See identical proteins and their annotated locations for NP_036588.1

    Status: REVIEWED

    Source sequence(s)
    AF150089, AI498204, CB106298
    Consensus CDS
    CCDS7959.1
    UniProtKB/Swiss-Prot
    A8K136, P62072, Q9WV99, Q9WVA0, Q9Y5J8
    Related
    ENSP00000257245.4, ENST00000257245.9
    Conserved Domains (1) summary
    pfam02953
    Location:7 → 69
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    57528464..57530754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448436.2 → XP_024304204.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

    UniProtKB/Swiss-Prot
    A8K136, P62072, Q9WV99, Q9WVA0, Q9Y5J8
    Related
    ENSP00000433627.1, ENST00000525158.1
    Conserved Domains (1) summary
    pfam02953
    Location:7 → 69
    zf-Tim10_DDP; Tim10/DDP family zinc finger

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    57478642..57492843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368410.1 → XP_054224385.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

    UniProtKB/Swiss-Prot
    A8K136, P62072, Q9WV99, Q9WVA0, Q9Y5J8

  2. XM_054368409.1 → XP_054224384.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

    UniProtKB/Swiss-Prot
    A8K136, P62072, Q9WV99, Q9WVA0, Q9Y5J8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62072.1 GenPept UniProtKB/Swiss-Prot:P62072

Gene LinkOut

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