Peg12 paternally expressed 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Peg12provided by MGI
Official Full Name: paternally expressed 12provided by MGI
Primary source: MGI:MGI:1351637
See related: Ensembl:ENSMUSG00000070526 AllianceGenome:MGI:1351637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Frat3
Summary: Predicted to enable molecular function inhibitor activity. Acts upstream of or within embryonic axis specification. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including hemolymphoid system; liver; lung; nervous system; and placenta. Orthologous to human FRAT1 (FRAT regulator of WNT signaling pathway 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

Location:: 7 C; 7 34.38 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (62111619..62114258, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (62461871..62464510, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Frat3 expression may contribute to the phenotype of mouse models of Prader-Willi syndrome
Title: Retrotransposed genes such as Frat3 in the mouse Chromosome 7C Prader-Willi syndrome region acquire the imprinted status of their insertion site.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548359

NoName (e-PCR)
- UniSTS:548360

NoName (e-PCR)
- UniSTS:494171

NoName (e-PCR)
- UniSTS:485235

NoName (e-PCR)
- UniSTS:237939

Peg12 (e-PCR), detects polymorphism
- UniSTS:547462

Peg12 (e-PCR), detects polymorphism
- UniSTS:265611

Peg12 (e-PCR), detects polymorphism
- UniSTS:532152

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic axis specification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: paternally expressed 12

Names: frequently rearranged in advanced T-cell lymphomas 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.