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GOLGA1 golgin A1 [ Homo sapiens (human) ]

Gene ID: 2800, updated on 28-Oct-2024

Summary

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Official Symbol
GOLGA1provided by HGNC
Official Full Name
golgin A1provided by HGNC
Primary source
HGNC:HGNC:4424
See related
Ensembl:ENSG00000136935 MIM:602502; AllianceGenome:HGNC:4424
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
golgin-97
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in testis (RPKM 12.9), skin (RPKM 6.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See GOLGA1 in Genome Data Viewer
Location:
9q33.3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124878275..124948043, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137076588..137151003, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127640554..127703362, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127620824-127621106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127621747-127622248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127622249-127622748 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127623737-127624360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127634813-127635313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127643063-127643616 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127646402-127646543 Neighboring gene ribosomal protein L35 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127662503-127663016 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127665639-127666139 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127681363-127681624 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127702954-127703454 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127703455-127703955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28998 Neighboring gene suppressor of cancer cell invasion Neighboring gene NANOG hESC enhancer GRCh37_chr9:127737373-127737931 Neighboring gene frataxin pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127806191-127806703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127806704-127807217 Neighboring gene uncharacterized LOC124902355

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97. Lock JG, et al. Traffic, 2005 Dec. PMID 16262725
  2. Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome. Griffith KJ, et al. Arthritis Rheum, 1997 Sep. PMID 9324025
  3. A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis. Alzhanova D, et al. Virology, 2007 Jun 5. PMID 17276477, Free PMC Article
  4. Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network. Lu L, et al. Mol Biol Cell, 2004 Oct. PMID 15269279, Free PMC Article
  5. FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network. Jing J, et al. Mol Biol Cell, 2010 Sep 1. PMID 20610657, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane.
    Title: PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane.
  2. Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers.
    Title: Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers.
  3. FIP1/RCP binding to Golgin-97 is required for tethering and fusion of recycling endosome-derived retrograde transport vesicles to the trans-Golgi network.
    Title: FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Selective and essential component of the tubulovesicular carriers transporting E-cadherin out of the trans-Golgi network.
    Title: E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97.
  7. The ability of the four mammalian GRIP domain proteins, p230, golgin-97, GCC88, and GCC185 to interact is reported.
    Title: The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.
  8. Data show that Arl1 regulates the membrane recruitment of Golgin-97, which plays a role in transport from the endosome to the trans-Golgi network.
    Title: Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network.
  9. Using RNA interference approach, it was demonstrated that a cellular trans-Golgi network membrane protein, golgin-97, is essential for Vaccinia virus replication.
    Title: A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with golgin A1 (GOLGA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33154

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
golgin subfamily A member 1
Names
gap junction protein, alpha 4, 37kD
golgi autoantigen, golgin subfamily a, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002077.4 → NP_002068.2  golgin subfamily A member 1

    Status: REVIEWED

    Source sequence(s)
    AL354928, AL451125
    Consensus CDS
    CCDS6860.1
    UniProtKB/Swiss-Prot
    Q5T164, Q8IYZ9, Q92805
    UniProtKB/TrEMBL
    B4DYI0
    Related
    ENSP00000362656.4, ENST00000373555.9
    Conserved Domains (3) summary
    smart00755
    Location:692 → 737
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:249 → 649
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:121 → 447
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    124878275..124948043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423242.1 → XP_047279198.1  golgin subfamily A member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T164, Q8IYZ9, Q92805

  2. XM_006717063.5 → XP_006717126.1  golgin subfamily A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006717126.1

    UniProtKB/Swiss-Prot
    Q5T164, Q8IYZ9, Q92805
    UniProtKB/TrEMBL
    B4DYI0
    Conserved Domains (3) summary
    smart00755
    Location:692 → 737
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:249 → 649
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:121 → 447
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_005251929.5 → XP_005251986.1  golgin subfamily A member 1 isoform X1

    See identical proteins and their annotated locations for XP_005251986.1

    UniProtKB/Swiss-Prot
    Q5T164, Q8IYZ9, Q92805
    UniProtKB/TrEMBL
    B4DYI0
    Conserved Domains (3) summary
    smart00755
    Location:692 → 737
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:249 → 649
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:121 → 447
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_006717062.5 → XP_006717125.1  golgin subfamily A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006717125.1

    UniProtKB/Swiss-Prot
    Q5T164, Q8IYZ9, Q92805
    UniProtKB/TrEMBL
    B4DYI0
    Conserved Domains (3) summary
    smart00755
    Location:692 → 737
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:249 → 649
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:121 → 447
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_047423241.1 → XP_047279197.1  golgin subfamily A member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T164, Q8IYZ9, Q92805

RNA

  1. XR_929766.2 RNA Sequence

    Related
    ENST00000475407.5

  2. XR_007061280.1 RNA Sequence

  3. XR_007061279.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    137076588..137151003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362760.1 → XP_054218735.1  golgin subfamily A member 1 isoform X1

  2. XM_054362757.1 → XP_054218732.1  golgin subfamily A member 1 isoform X1

  3. XM_054362758.1 → XP_054218733.1  golgin subfamily A member 1 isoform X1

  4. XM_054362761.1 → XP_054218736.1  golgin subfamily A member 1 isoform X1

  5. XM_054362759.1 → XP_054218734.1  golgin subfamily A member 1 isoform X1

RNA

  1. XR_008487981.1 RNA Sequence

  2. XR_008487982.1 RNA Sequence

  3. XR_008487983.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92805.3 GenPept UniProtKB/Swiss-Prot:Q92805

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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