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cdon cell adhesion associated, oncogene regulated [ Danio rerio (zebrafish) ]

Gene ID: 280652, updated on 17-Sep-2024

Summary

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Official Symbol
cdonprovided by ZNC
Official Full Name
cell adhesion associated, oncogene regulatedprovided by ZNC
Primary source
ZFIN:ZDB-GENE-021115-4
See related
Ensembl:ENSDARG00000061328 AllianceGenome:ZFIN:ZDB-GENE-021115-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb507; wu:fa10c03; wu:fb94b11; zgc:158240
Summary
Acts upstream of or within negative regulation of smoothened signaling pathway. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See cdon in Genome Data Viewer
Location:
chromosome: 18
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44053013..44129028, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44059154..44135574, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene bcl9 like Neighboring gene V-set and immunoglobulin domain-containing protein 10-like 2 Neighboring gene uncharacterized LOC137488334 Neighboring gene si:ch211-151h10.2 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 179

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cdon promotes neural crest migration by regulating N-cadherin localization. Powell DR, et al. Dev Biol, 2015 Nov 15. PMID 26256768, Free PMC Article
  2. Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. Cardozo MJ, et al. Nat Commun, 2014 Jul 8. PMID 25001599, Free PMC Article
  3. Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Bergeron SA, et al. Development, 2011 Jan. PMID 21115611, Free PMC Article
  4. Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Wang X, et al. Biol Open, 2013. PMID 24244857, Free PMC Article
  5. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.
    Title: Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.
  2. Cdon is required to localize N-cadherin to the cell membrane in migratory neural crest cells for directed migration.
    Title: Cdon promotes neural crest migration by regulating N-cadherin localization.
  3. In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog protein, thereby limiting its dispersion.
    Title: Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell adhesion molecule-related/down-regulated by oncogenes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081628.1 → NP_001075097.1  cell adhesion molecule-related/down-regulated by oncogenes precursor

    See identical proteins and their annotated locations for NP_001075097.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133076
    UniProtKB/TrEMBL
    A2RUW8, Q1L8D0
    Related
    ENSDARP00000081773.4, ENSDART00000087339.6
    Conserved Domains (5) summary
    smart00408
    Location:239 → 294
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:230 → 310
    IG_like; Immunoglobulin like
    cd00063
    Location:594 → 685
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:315 → 399
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:317 → 399
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    44053013..44129028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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