bckdk branched chain ketoacid dehydrogenase kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bckdkprovided by ZNC
Official Full Name: branched chain ketoacid dehydrogenase kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021204-1
See related: Ensembl:ENSDARG00000016904 AllianceGenome:ZFIN:ZDB-GENE-021204-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb233; zgc:55984; wu:fa04g07; wu:fb80b08
Summary: Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in regulation of acetyl-CoA biosynthetic process from pyruvate and regulation of glucose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including midbrain neural keel; midbrain neural rod; neural plate; pancreatic system; and primary neurons. Human ortholog(s) of this gene implicated in branched-chain keto acid dehydrogenase kinase deficiency. Orthologous to human BCKDK (branched chain keto acid dehydrogenase kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (61508336..61554010)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (60823615..60869289)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb80b08.x1 (e-PCR)
- UniSTS:203454

fa04g07.s1 (e-PCR)
- UniSTS:202203

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: branched-chain alpha-ketoacid dehydrogenase kinase

Names: branched chain alpha-ketoacid dehydrogenase kinase

NP_998225.2

EC 2.7.11.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213060.2 → NP_998225.2 branched-chain alpha-ketoacid dehydrogenase kinase

Status: VALIDATED

Source sequence(s)

AL935280, EH507568, GW712489

UniProtKB/TrEMBL

A0A8M1PEI5, B0R159

Related

ENSDARP00000021993.5, ENSDART00000023676.6

Conserved Domains (3) summary

smart00387
Location:283 → 417

HATPase_c; Histidine kinase-like ATPases

COG0642
Location:247 → 416

BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]

pfam10436
Location:86 → 239

BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase