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dag1 dystroglycan 1 [ Danio rerio (zebrafish) ]

Gene ID: 286829, updated on 2-Nov-2024

Summary

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Official Symbol
dag1provided by ZNC
Official Full Name
dystroglycan 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-021223-1
See related
Ensembl:ENSDARG00000016153 AllianceGenome:ZFIN:ZDB-GENE-021223-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dag; wu:fb83d06; wu:fi25f06; wu:fi37b08; zgc:109786
Summary
Enables laminin binding activity. Acts upstream of or within several processes, including T-tubule organization; skeletal muscle organ development; and somatic muscle development. Located in sarcolemma. Is expressed in several structures, including mesoderm; nervous system; pronephros; trunk; and trunk musculature. Used to study muscular dystrophy-dystroglycanopathy type B1. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dag1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (33132024..33194805)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (33177382..33240229)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 15B Neighboring gene poly(rC) binding protein 4 Neighboring gene nicolin 1 Neighboring gene glutamate metabotropic receptor 7 Neighboring gene uncharacterized LOC137488973

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Duplication of the dystroglycan gene in most branches of teleost fish. Pavoni E, et al. BMC Mol Biol, 2007 May 17. PMID 17509131, Free PMC Article
  2. Insights from molecular dynamics simulations: structural basis for the V567D mutation-induced instability of zebrafish alpha-dystroglycan and comparison with the murine model. Pirolli D, et al. PLoS One, 2014. PMID 25078606, Free PMC Article
  3. Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos. Parsons MJ, et al. Development, 2002 Jul. PMID 12091319
  4. Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation. Lefebvre JL, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17284594, Free PMC Article
  5. Developmental defects in a zebrafish model for muscular dystrophies associated with the loss of fukutin-related protein (FKRP). Thornhill P, et al. Brain, 2008 Jun. PMID 18477595

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fkrp plays an early and essential role in muscle, myotendinous junction, and neuromuscular junction development. The data also indicate that, at least in the zebrafish model, FKRP-associated dystroglycanopathy does not exactly phenocopy dystroglycan deficiency.
    Title: NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy.
  2. Patchytail fish contain a point mutation (c.1700T>A) in dag1, resulting in a missense change leading to skeletal muscle defects, brain abnormalities and ocular defects in posterior as well as anterior chambers.
    Title: The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies.
  3. genetic evidence that neuromuscular synapse formation can occur in the absence of MuSK and that the combinatorial function of UnpFL/MuSK and dystroglycan generates diverse patterns of vertebrate neuromuscular innervation
    Title: Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation.
  4. Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos.
    Title: Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109786

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables laminin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T-tubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in morphogenesis of an epithelium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle attachment IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within muscle attachment IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nerve development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within receptor clustering IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dystroglycan complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dystrophin-associated glycoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of dystrophin-associated glycoprotein complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dystroglycan 1
Names
dystrophin-associated glycoprote
dystrophin-associated glycoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173274.1 → NP_775381.1  dystroglycan 1 precursor

    See identical proteins and their annotated locations for NP_775381.1

    Status: PROVISIONAL

    Source sequence(s)
    AF483476
    UniProtKB/TrEMBL
    Q8JHU7
    Related
    ENSDARP00000020759.6, ENSDART00000004504.8
    Conserved Domains (4) summary
    cd11303
    Location:79 → 171
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:192 → 314
    alpha_DG_C; C-terminal domain of alpha dystroglycan
    smart00736
    Location:476 → 570
    CADG; Dystroglycan-type cadherin-like domains
    pfam05454
    Location:580 → 866
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    33132024..33194805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296487.4 → XP_009294762.1  dystroglycan 1 isoform X1

    See identical proteins and their annotated locations for XP_009294762.1

    UniProtKB/TrEMBL
    A0A8M3AUX6, F1QMH7
    Conserved Domains (4) summary
    cd11303
    Location:79 → 171
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:192 → 314
    alpha_DG_C; C-terminal domain of alpha dystroglycan
    smart00736
    Location:476 → 570
    CADG; Dystroglycan-type cadherin-like domains
    pfam05454
    Location:580 → 866
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

  2. XM_005170544.5 → XP_005170601.1  dystroglycan 1 isoform X1

    See identical proteins and their annotated locations for XP_005170601.1

    UniProtKB/TrEMBL
    A0A8M3AUX6, F1QMH7
    Related
    ENSDARP00000106371.1, ENSDART00000126885.3
    Conserved Domains (4) summary
    cd11303
    Location:79 → 171
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:192 → 314
    alpha_DG_C; C-terminal domain of alpha dystroglycan
    smart00736
    Location:476 → 570
    CADG; Dystroglycan-type cadherin-like domains
    pfam05454
    Location:580 → 866
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
Nucleotide Protein Strain
Heading Accession and Version

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