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mc5rb melanocortin 5b receptor [ Danio rerio (zebrafish) ]

Gene ID: 286835, updated on 12-Sep-2024

Summary

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Official Symbol
mc5rbprovided by ZNC
Official Full Name
melanocortin 5b receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-021223-4
See related
Ensembl:ENSDARG00000054946 AllianceGenome:ZFIN:ZDB-GENE-021223-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mc5br; mc5ra; zMC5b; zgc:194217
Summary
Enables protein heterodimerization activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human MC5R (melanocortin 5 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See mc5rb in Genome Data Viewer
Location:
chromosome: 16
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (30578937..30594683, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (30624739..30636760, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene lamin A Neighboring gene melanocortin 2 receptor Neighboring gene family with sequence similarity 210 member Ab Neighboring gene low density lipoprotein receptor class A domain containing 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning, tissue distribution, and pharmacological characterization of blunt snout bream (Megalobrama amblycephala) melanocortin-5 receptor. Liao S, et al. Fish Physiol Biochem, 2019 Feb. PMID 30288633
  2. Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish. Zhu M, et al. J Mol Endocrinol, 2018 Oct 1. PMID 30400043
  3. Creation of a genetic model of obesity in a teleost. Song Y, et al. FASEB J, 2007 Jul. PMID 17341684
  4. Spliceosomal intron insertions in genome compacted ray-finned fishes as evident from phylogeny of MC receptors, also supported by a few other GPCRs. Kumar A, et al. PLoS One, 2011. PMID 21850219, Free PMC Article
  5. Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). Sánchez E, et al. Am J Physiol Regul Integr Comp Physiol, 2009 May. PMID 19225141, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables melanocortin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables melanocortin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
melanocortin 5b receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173280.1 → NP_775387.1  melanocortin 5b receptor

    See identical proteins and their annotated locations for NP_775387.1

    Status: PROVISIONAL

    Source sequence(s)
    AY078991
    UniProtKB/TrEMBL
    Q8JGW1
    Related
    ENSDARP00000071694.3, ENSDART00000077226.4
    Conserved Domains (2) summary
    pfam00001
    Location:55 → 298
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:45 → 169
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    30578937..30594683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158169.5 → XP_005158226.1  melanocortin 5b receptor isoform X1

    See identical proteins and their annotated locations for XP_005158226.1

    UniProtKB/TrEMBL
    A0A8M2B532, F1Q9X6
    Conserved Domains (2) summary
    pfam00001
    Location:55 → 298
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:45 → 169
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version

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