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Nars1 asparaginyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291556, updated on 2-Nov-2024

Summary

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Official Symbol
Nars1provided by RGD
Official Full Name
asparaginyl-tRNA synthetase 1provided by RGD
Primary source
RGD:1307238
See related
EnsemblRapid:ENSRNOG00000017852 AllianceGenome:RGD:1307238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nars; LRRGT00113
Summary
Predicted to enable CCR3 chemokine receptor binding activity; asparagine-tRNA ligase activity; and protein dimerization activity. Predicted to be involved in asparaginyl-tRNA aminoacylation; cell migration; and cerebral cortex development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 412.4), Liver (RPKM 323.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nars1 in Genome Data Viewer
Location:
18q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (60259506..60275782, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (57989308..58005584, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59986350..60002644, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene one cut homeobox 2 Neighboring gene ferrochelatase Neighboring gene ATPase phospholipid transporting 8B1 Neighboring gene SPT2 chromatin protein domain containing 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity. Park JS, et al. Int J Biol Macromol, 2018 Dec. PMID 30171954
  2. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. Beaulande M, et al. Nucleic Acids Res, 1998 Jan 15. PMID 9421509, Free PMC Article
  3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  4. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116236

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CCR3 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables asparagine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in asparaginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparaginyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
asparagine--tRNA ligase, cytoplasmic
Names
asparaginyl-tRNA synthetase, cytoplasmic
NP_001020806.2
NP_001136421.1
NP_001385496.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025635.3 → NP_001020806.2  asparagine--tRNA ligase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_001020806.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JUE7, A6IXP1, F1LPV0
    Conserved Domains (3) summary
    COG0017
    Location:135 → 558
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00776
    Location:235 → 554
    AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
    cd04323
    Location:137 → 219
    AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

  2. NM_001142949.2 → NP_001136421.1  asparagine--tRNA ligase, cytoplasmic isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has several differences near the N-terminus, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1LML0, Q6TUD1
    Related
    ENSRNOP00000055935.2, ENSRNOT00000059162.6
    Conserved Domains (3) summary
    COG0017
    Location:84 → 507
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00776
    Location:184 → 503
    AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
    cd04323
    Location:86 → 168
    AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

  3. NM_001398567.1 → NP_001385496.1  asparagine--tRNA ligase, cytoplasmic isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    Related
    ENSRNOP00000024264.7, ENSRNOT00000024264.10
    Conserved Domains (1) summary
    COG0017
    Location:136 → 559
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    60259506..60275782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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