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Cuedc2 CUE domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294009, updated on 10-Oct-2024

Summary

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Official Symbol
Cuedc2provided by RGD
Official Full Name
CUE domain containing 2provided by RGD
Primary source
RGD:1308096
See related
EnsemblRapid:ENSRNOG00000019574 AllianceGenome:RGD:1308096
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin binding activity. Predicted to act upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Orthologous to human CUEDC2 (CUE domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 65.4), Spleen (RPKM 52.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cuedc2 in Genome Data Viewer
Location:
1q54
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255133479..255142016, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245192057..245200594, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266078107..266087057, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene F-box and leucine-rich repeat protein 15 Neighboring gene similar to human chromosome 10 open reading frame 95 Neighboring gene microRNA 146b Neighboring gene major facilitator superfamily domain containing 13A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult. Huang Y, et al. Aging (Albany NY), 2021 Jan 20. PMID 33494071, Free PMC Article
  2. Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer. Chen Y, et al. Cell Rep, 2014 Jun 26. PMID 24882011
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult.
    Title: CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC156734

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CUE domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079886.1 → NP_001073355.1  CUE domain-containing protein 2

    See identical proteins and their annotated locations for NP_001073355.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127518
    UniProtKB/Swiss-Prot
    A1L131
    UniProtKB/TrEMBL
    A0A8I5ZQ90
    Related
    ENSRNOP00000026609.7, ENSRNOT00000026609.8
    Conserved Domains (1) summary
    cd14367
    Location:126 → 166
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    255133479..255142016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287248.1 → XP_063143318.1  CUE domain-containing protein 2 isoform X5

    Related
    ENSRNOP00000080530.2, ENSRNOT00000097448.2

  2. XM_008760410.3 → XP_008758632.1  CUE domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    cd14367
    Location:232 → 272
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  3. XM_006231466.4 → XP_006231528.1  CUE domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006231528.1

    UniProtKB/Swiss-Prot
    A1L131
    UniProtKB/TrEMBL
    A0A8I5ZQ90
    Conserved Domains (1) summary
    cd14367
    Location:126 → 166
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  4. XM_006231460.4 → XP_006231522.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006231522.1

    UniProtKB/TrEMBL
    A0A8I5ZQ90, A0A8L2UK80, A6JHM2
    Conserved Domains (1) summary
    cd14367
    Location:144 → 184
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  5. XM_006231458.4 → XP_006231520.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006231520.1

    UniProtKB/TrEMBL
    A0A8I5ZQ90, A0A8L2UK80, A6JHM2
    Conserved Domains (1) summary
    cd14367
    Location:144 → 184
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  6. XM_017589041.2 → XP_017444530.1  CUE domain-containing protein 2 isoform X6

  7. XM_008760411.4 → XP_008758633.3  CUE domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZQ90
    Conserved Domains (1) summary
    cd14367
    Location:144 → 184
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  8. XM_006231462.5 → XP_006231524.3  CUE domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQ90, A0A8L2UK80, A6JHM2
    Conserved Domains (1) summary
    cd14367
    Location:144 → 184
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  9. XM_008760409.4 → XP_008758631.2  CUE domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A1L131
    UniProtKB/TrEMBL
    A0A8I5ZQ90
    Conserved Domains (1) summary
    cd14367
    Location:126 → 166
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  10. XM_039109080.2 → XP_038965008.1  CUE domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQ90, A0A8L2UK80, A6JHM2
    Conserved Domains (1) summary
    cd14367
    Location:144 → 184
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  11. XM_063287257.1 → XP_063143327.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A1L131
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L131.1 GenPept UniProtKB/Swiss-Prot:A1L131

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