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Pi16 peptidase inhibitor 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294312, updated on 17-Aug-2024

Summary

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Official Symbol
Pi16provided by RGD
Official Full Name
peptidase inhibitor 16provided by RGD
Primary source
RGD:1304760
See related
EnsemblRapid:ENSRNOG00000000525 AllianceGenome:RGD:1304760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be active in extracellular space. Orthologous to human PI16 (peptidase inhibitor 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 183.3), Lung (RPKM 132.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pi16 in Genome Data Viewer
Location:
20p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7377739..7387003)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7376073..7385386)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6923176..6932786)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 1 Neighboring gene transfer RNA threonine (anticodon AGU) 18 Neighboring gene similar to human chromosome 6 open reading frame 89 Neighboring gene uncharacterized LOC120098949 Neighboring gene uncharacterized LOC134483863 Neighboring gene mitochondrial carrier 1 Neighboring gene FYVE, RhoGEF and PH domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart. Frost RJ, et al. Circulation, 2007 Oct 16. PMID 17909105
  2. Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts. Deng M, et al. J Cell Mol Med, 2020 May. PMID 32227584, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
    Title: Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptidase inhibitor 16
Names
protease inhibitor 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170481.2 → NP_001163952.1  peptidase inhibitor 16 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A6JJU6
    Related
    ENSRNOP00000000632.8, ENSRNOT00000000632.9
    Conserved Domains (1) summary
    cd05559
    Location:39 → 172
    SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...

  2. NM_001393815.1 → NP_001380744.1  peptidase inhibitor 16 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    Conserved Domains (1) summary
    cd05559
    Location:39 → 172
    CAP_PI16_HrTT-1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    7377739..7387003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098532.2 → XP_038954460.1  peptidase inhibitor 16 isoform X1

    Related
    ENSRNOP00000076126.3, ENSRNOT00000093209.3
    Conserved Domains (1) summary
    cd05559
    Location:152 → 285
    CAP_PI16_HrTT-1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein

RNA

  1. XR_362046.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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