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Pcsk7 proprotein convertase subtilisin/kexin type 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29606, updated on 2-Nov-2024

Summary

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Official Symbol
Pcsk7provided by RGD
Official Full Name
proprotein convertase subtilisin/kexin type 7provided by RGD
Primary source
RGD:3275
See related
EnsemblRapid:ENSRNOG00000017478 AllianceGenome:RGD:3275
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PC7
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in Golgi membrane and trans-Golgi network. Orthologous to human PCSK7 (proprotein convertase subtilisin/kexin type 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 95.3), Kidney (RPKM 94.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pcsk7 in Genome Data Viewer
Location:
8q22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55098821..55121416)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46202079..46224699)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50200069..50222655)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 164 Neighboring gene beta-secretase 1 Neighboring gene ring finger protein 214 Neighboring gene transgelin Neighboring gene uncharacterized LOC120094332 Neighboring gene SID1 transmembrane family, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The proprotein convertase PC7: unique zymogen activation and trafficking pathways. Rousselet E, et al. J Biol Chem, 2011 Jan 28. PMID 21075846, Free PMC Article
  2. Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase. van de Loo JW, et al. J Biol Chem, 1997 Oct 24. PMID 9341152
  3. cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Seidah NG, et al. Proc Natl Acad Sci U S A, 1996 Apr 16. PMID 8622945, Free PMC Article
  4. Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport. Kato S, et al. Am J Physiol Lung Cell Mol Physiol, 2013 Jul 15. PMID 23686857, Free PMC Article
  5. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. Wickham L, et al. J Neurochem, 2005 Jan. PMID 15606899

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
    Title: Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
  2. PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.
    Title: The proprotein convertase PC7: unique zymogen activation and trafficking pathways.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
proprotein convertase subtilisin/kexin type 7
Names
prohormone convertase 7
prohormone convertase PC7
proprotein convertase 7
proprotein convertase PC7
rPC7
subtilisin/kexin-like protease PC7
NP_062119.1
XP_038936896.1
XP_063121098.1
XP_063121099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019246.2 → NP_062119.1  proprotein convertase subtilisin/kexin type 7 precursor

    See identical proteins and their annotated locations for NP_062119.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q62849
    UniProtKB/TrEMBL
    A6J459
    Related
    ENSRNOP00000023677.3, ENSRNOT00000023677.6
    Conserved Domains (4) summary
    cd04059
    Location:144 → 439
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:195 → 439
    Peptidase_S8; Subtilase family
    pfam01483
    Location:524 → 611
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:52 → 140
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    55098821..55121416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265028.1 → XP_063121098.1  proprotein convertase subtilisin/kexin type 7 isoform X1

    UniProtKB/Swiss-Prot
    Q62849
    UniProtKB/TrEMBL
    A6J459

  2. XM_039080968.2 → XP_038936896.1  proprotein convertase subtilisin/kexin type 7 isoform X2

    Conserved Domains (2) summary
    cd04059
    Location:2 → 224
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:309 → 396
    P_proprotein; Proprotein convertase P-domain

  3. XM_063265029.1 → XP_063121099.1  proprotein convertase subtilisin/kexin type 7 isoform X3

RNA

  1. XR_005487748.2 RNA Sequence

  2. XR_005487749.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62849.1 GenPept UniProtKB/Swiss-Prot:Q62849

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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