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Gxylt1 glucoside xylosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300173, updated on 17-Aug-2024

Summary

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Official Symbol
Gxylt1provided by RGD
Official Full Name
glucoside xylosyltransferase 1provided by RGD
Primary source
RGD:1563062
See related
EnsemblRapid:ENSRNOG00000005234 AllianceGenome:RGD:1563062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Glt8d3
Summary
Predicted to enable UDP-xylosyltransferase activity. Predicted to be involved in O-glycan processing. Predicted to be integral component of membrane. Orthologous to human GXYLT1 (glucoside xylosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 69.3), Lung (RPKM 58.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q35
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (126280349..126320803, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (124400896..124434682, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (134447578..134495858, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479776 Neighboring gene uncharacterized LOC102552792 Neighboring gene uncharacterized LOC134479777 Neighboring gene YY1 associated factor 2 Neighboring gene 60S ribosomal protein L30 pseudogene Neighboring gene uncharacterized LOC134479778

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. Sethi MK, et al. J Biol Chem, 2010 Jan 15. PMID 19940119, Free PMC Article
  2. Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. Iwanaga R, et al. Oncogene, 2006 Mar 16. PMID 16288221
  3. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Pandey A, et al. Glycobiology, 2018 Nov 1. PMID 30169771, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-xylosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-xylosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-xylosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in O-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in O-glycan processing ISO
Inferred from Sequence Orthology
more info
  
involved_in O-glycan processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucoside xylosyltransferase 1
Names
S33-D
glycosyltransferase 8 domain containing 3
glycosyltransferase 8 domain-containing protein 3
NP_001094357.1
XP_006242254.1
XP_038934832.1
XP_038934833.1
XP_038934834.1
XP_038934835.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100887.1 → NP_001094357.1  glucoside xylosyltransferase 1

    See identical proteins and their annotated locations for NP_001094357.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q6GX83
    UniProtKB/TrEMBL
    A6K7S6
    Related
    ENSRNOP00000055150.2, ENSRNOT00000058349.5
    Conserved Domains (2) summary
    cd06430
    Location:111 → 411
    GT8_like_2; GT8_like_2 represents a subfamily of GT8 with unknown function
    COG1442
    Location:183 → 340
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    126280349..126320803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242192.5 → XP_006242254.1  glucoside xylosyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFF2, A6K7S5
    Related
    ENSRNOP00000091433.1, ENSRNOT00000099240.2
    Conserved Domains (2) summary
    cd06430
    Location:80 → 380
    GT8_like_2; GT8_like_2 represents a subfamily of GT8 with unknown function
    COG1442
    Location:152 → 309
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

  2. XM_039078904.2 → XP_038934832.1  glucoside xylosyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    B2RZ91
    Related
    ENSRNOP00000073028.1, ENSRNOT00000081104.3
    Conserved Domains (1) summary
    cd06430
    Location:1 → 301
    GT8_like_2; GT8_like_2 represents a subfamily of GT8 with unknown function

  3. XM_039078907.2 → XP_038934835.1  glucoside xylosyltransferase 1 isoform X5

    Conserved Domains (1) summary
    cl11394
    Location:4 → 225
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  4. XM_039078906.2 → XP_038934834.1  glucoside xylosyltransferase 1 isoform X4

    Conserved Domains (1) summary
    cl11394
    Location:80 → 252
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  5. XM_039078905.2 → XP_038934833.1  glucoside xylosyltransferase 1 isoform X3

    Conserved Domains (1) summary
    cl11394
    Location:111 → 283
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GX83.2 GenPept UniProtKB/Swiss-Prot:Q6GX83

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