U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mpp7a MAGUK p55 scaffold protein 7a [ Danio rerio (zebrafish) ]

Gene ID: 30166, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
mpp7aprovided by ZNC
Official Full Name
MAGUK p55 scaffold protein 7aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-991209-8
See related
Ensembl:ENSDARG00000102470 AllianceGenome:ZFIN:ZDB-GENE-991209-8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hmp; dlg3; mpp7
Summary
Predicted to be located in adherens junction; bicellular tight junction; and membrane. Is expressed in several structures, including hatching gland; nervous system; notochord; otic vesicle; and pectoral fin bud. Orthologous to human MPP7 (MAGUK p55 scaffold protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mpp7a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (23175962..23365873, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (23054743..23244652, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene mohawk homeobox a Neighboring gene outer dynein arm docking complex subunit 2 Neighboring gene WW domain containing adaptor with coiled-coil a Neighboring gene uncharacterized LOC103911922 Neighboring gene BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density. Xiao SM, et al. Hum Mol Genet, 2012 Apr 1. PMID 22171069
  2. U6 promoter-driven siRNA injection has nonspecific effects in zebrafish. Wang L, et al. Biochem Biophys Res Commun, 2010 Jan 15. PMID 20026059
  3. A recessive mutation leading to vertebral ankylosis in zebrafish is associated with amino acid alterations in the homologue of the human membrane-associated guanylate kinase DLG3. König C, et al. Mech Dev, 1999 Aug. PMID 10446262
  4. Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis. Wu VM, et al. Development, 2007 Mar. PMID 17267446, Free PMC Article
  5. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Wang L, et al. Development, 2013 Jul. PMID 23698347

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in protein localization to adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
MAGUK p55 subfamily member 7
Names
humpback
membrane palmitoylated protein 7a
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
protein humpback

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130976.1 → NP_571051.1  MAGUK p55 subfamily member 7

    See identical proteins and their annotated locations for NP_571051.1

    Status: PROVISIONAL

    Source sequence(s)
    AF124435
    UniProtKB/Swiss-Prot
    Q6P0D7
    Related
    ENSDARP00000152963.1, ENSDART00000181711.1
    Conserved Domains (5) summary
    smart00569
    Location:74 → 125
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    smart00072
    Location:377 → 563
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137 → 217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:369 → 561
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:232 → 292
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    23175962..23365873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306585.3 → XP_009304860.1  MAGUK p55 subfamily member 7 isoform X4

    See identical proteins and their annotated locations for XP_009304860.1

    UniProtKB/Swiss-Prot
    Q6P0D7, Q9PWC1, Q9W7F1
    Related
    ENSDARP00000141751.1, ENSDART00000170376.3
    Conserved Domains (5) summary
    smart00569
    Location:74 → 125
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    smart00072
    Location:377 → 563
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137 → 217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:369 → 561
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:232 → 292
    SH3; Src Homology 3 domain superfamily

  2. XM_021480018.1 → XP_021335693.1  MAGUK p55 subfamily member 7 isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q869
    Conserved Domains (4) summary
    smart00569
    Location:74 → 125
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    smart00072
    Location:377 → 582
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137 → 217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17036
    Location:232 → 292
    SH3; Src Homology 3 domain superfamily

  3. XM_009306583.3 → XP_009304858.1  MAGUK p55 subfamily member 7 isoform X2

    See identical proteins and their annotated locations for XP_009304858.1

    UniProtKB/TrEMBL
    A0A8M3B7B3
    Conserved Domains (5) summary
    smart00569
    Location:74 → 125
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    smart00072
    Location:403 → 589
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137 → 217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:395 → 587
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:232 → 292
    SH3; Src Homology 3 domain superfamily

  4. XM_021480017.1 → XP_021335692.1  MAGUK p55 subfamily member 7 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PW28
    Conserved Domains (4) summary
    smart00569
    Location:74 → 125
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    smart00072
    Location:403 → 608
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137 → 217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17036
    Location:232 → 292
    SH3; Src Homology 3 domain superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394841.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    220159..222774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P0D7.1 GenPept UniProtKB/Swiss-Prot:Q6P0D7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous