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ikzf1 IKAROS family zinc finger 1 (Ikaros) [ Danio rerio (zebrafish) ]

Gene ID: 30177, updated on 28-Oct-2024

Summary

Official Symbol
ikzf1provided by ZNC
Official Full Name
IKAROS family zinc finger 1 (Ikaros)provided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-304
See related
Ensembl:ENSDARG00000013539 AllianceGenome:ZFIN:ZDB-GENE-980526-304
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ikaros; znfn1a1
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; and common variable immunodeficiency 13. Orthologous to human IKZF1 (IKAROS family zinc finger 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See ikzf1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15957852..15994717, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15826860..15864090, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase Neighboring gene fidgetin-like 1 Neighboring gene uncharacterized LOC137487381 Neighboring gene uncharacterized LOC137487380 Neighboring gene sperm microtubule inner protein 7 Neighboring gene von Willebrand factor C domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General protein information

Preferred Names
DNA-binding protein Ikaros
Names
zinc finger protein, subfamily 1A, 1 (Ikaros)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130986.1NP_571061.1  DNA-binding protein Ikaros

    See identical proteins and their annotated locations for NP_571061.1

    Status: PROVISIONAL

    Source sequence(s)
    AF092175
    UniProtKB/TrEMBL
    O93581
    Related
    ENSDARP00000013960.5, ENSDART00000016430.7
    Conserved Domains (4) summary
    COG5048
    Location:132235
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164184
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:162184
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:176201
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    15957852..15994717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156620.5XP_005156677.1  DNA-binding protein Ikaros isoform X5

    UniProtKB/TrEMBL
    A0A8M2B2X4
    Related
    ENSDARP00000050480.3, ENSDART00000050481.5
    Conserved Domains (4) summary
    COG5048
    Location:114236
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:165185
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:163185
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:177202
    zf-H2C2_2; Zinc-finger double domain
  2. XM_068224899.1XP_068081000.1  DNA-binding protein Ikaros isoform X4

  3. XM_005156619.5XP_005156676.1  DNA-binding protein Ikaros isoform X3

    UniProtKB/TrEMBL
    A0A8M2B2R4
    Conserved Domains (3) summary
    COG5048
    Location:253360
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:229249
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:242266
    zf-H2C2_2; Zinc-finger double domain
  4. XM_005156618.5XP_005156675.1  DNA-binding protein Ikaros isoform X1

    UniProtKB/TrEMBL
    A0A8M2B2N6
    Related
    ENSDARP00000074176.3, ENSDART00000079724.4
    Conserved Domains (3) summary
    COG5048
    Location:254328
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:229249
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:242266
    zf-H2C2_2; Zinc-finger double domain
  5. XM_009307224.4XP_009305499.1  DNA-binding protein Ikaros isoform X2

    UniProtKB/TrEMBL
    A0A8M3AZ03
    Conserved Domains (4) summary
    COG5048
    Location:248371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268288
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:266288
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:280305
    zf-H2C2_2; Zinc-finger double domain