en1a engrailed homeobox 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: en1aprovided by ZNC
Official Full Name: engrailed homeobox 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-216
See related: Ensembl:ENSDARG00000014321 AllianceGenome:ZFIN:ZDB-GENE-980526-216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: en1; en-1; eng1; ENG-1; eng1a; zgc:100771
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis involved in innervation. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; midbrain hindbrain boundary neural rod; musculature system; pectoral fin bud; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (781049..785288, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (781416..785448, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Engrailed plays an evolutionarily conserved role in the separate innervation of vertebrate epaxial-hypaxial muscle.
Title: Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility.

Submit: New GeneRIF Correction

General gene information

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Markers

ENG1 (e-PCR)
- UniSTS:205346

eng1 (e-PCR), detects polymorphism
- UniSTS:205640

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis involved in innervation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein engrailed-1a

Names: engrailed 1a; homeobox protein en-1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131045.2 → NP_571120.2 homeobox protein engrailed-1a

Status: VALIDATED

Source sequence(s)

CABZ01070420

UniProtKB/Swiss-Prot

Q04896

UniProtKB/TrEMBL

Q68EL7

Related

ENSDARP00000023487.5, ENSDART00000012506.9

Conserved Domains (2) summary

pfam00046
Location:146 → 199

Homeobox; Homeobox domain

pfam10525
Location:201 → 230

Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain