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Srrm2 serine/arginine repetitive matrix 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302969, updated on 2-Nov-2024

Summary

Official Symbol
Srrm2provided by RGD
Official Full Name
serine/arginine repetitive matrix 2provided by RGD
Primary source
RGD:1310163
See related
EnsemblRapid:ENSRNOG00000058561 AllianceGenome:RGD:1310163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable C2H2 zinc finger domain binding activity and mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human SRRM2 (serine/arginine repetitive matrix 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 868.1), Kidney (RPKM 521.1) and 9 other tissues See more
Orthologs
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Genomic context

See Srrm2 in Genome Data Viewer
Location:
10q12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13320059..13353337)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12815471..12848750)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13128820..13162956)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene FLYWCH family member 2 Neighboring gene uncharacterized LOC134480759 Neighboring gene elongin B Neighboring gene serine protease 33

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/arginine repetitive matrix protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277154.1NP_001264083.1  serine/arginine repetitive matrix protein 2

    Status: VALIDATED

    Source sequence(s)
    BC166455, JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A0A2
    Related
    ENSRNOP00000086062.2, ENSRNOT00000116530.2
    Conserved Domains (3) summary
    PHA03247
    Location:19852442
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:292609
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    13320059..13353337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268912.1XP_063124982.1  serine/arginine repetitive matrix protein 2 isoform X1

  2. XM_039085853.2XP_038941781.1  serine/arginine repetitive matrix protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0A2
    Conserved Domains (3) summary
    PHA03247
    Location:19852442
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:292609
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2
  3. XM_039085854.2XP_038941782.1  serine/arginine repetitive matrix protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A0A2
    Conserved Domains (3) summary
    PHA03247
    Location:19842441
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:291608
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2
  4. XM_063268913.1XP_063124983.1  serine/arginine repetitive matrix protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A2Y2
    Related
    ENSRNOP00000083591.2, ENSRNOT00000100880.2
  5. XM_063268914.1XP_063124984.1  serine/arginine repetitive matrix protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6G2I7
    Related
    ENSRNOP00000078271.1, ENSRNOT00000116501.2
  6. XM_039085856.2XP_038941784.1  serine/arginine repetitive matrix protein 2 isoform X6

    Conserved Domains (1) summary
    cd21375
    Location:39102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2
  7. XM_039085855.2XP_038941783.1  serine/arginine repetitive matrix protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A0A2
    Conserved Domains (2) summary
    PHA03247
    Location:18892346
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:196513
    PHA03307; transcriptional regulator ICP4; Provisional
  8. XM_063268915.1XP_063124985.1  serine/arginine repetitive matrix protein 2 isoform X7

    UniProtKB/TrEMBL
    A6HCM7

RNA

  1. XR_005489792.2 RNA Sequence