ek1 eph-like kinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ek1provided by ZNC
Official Full Name: eph-like kinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-58
See related: Ensembl:ENSDARG00000020080 AllianceGenome:ZFIN:ZDB-GENE-990415-58
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rtk7; epha3; zgc:100780; etID309879.24
Summary: Predicted to enable GPI-linked ephrin receptor activity and transmembrane-ephrin receptor activity. Predicted to be involved in several processes, including axon development; ephrin receptor signaling pathway; and regulation of cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in early endosome. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in central nervous system and neural tube. Orthologous to human EPHA1 (EPH receptor A1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (27548487..27715238)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (27469328..27636079)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

U89295 (e-PCR)
- UniSTS:204671

AJ005028 (e-PCR)
- UniSTS:204701

zek1 (e-PCR)
- UniSTS:187056

rtk7 (e-PCR)
- UniSTS:205517

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in fasciculation of motor neuron axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in fasciculation of sensory neuron axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ephrin type-A receptor 3

Names: eph-like receptor tyrosine kinase 7; epha4d; tyrosine-protein kinase receptor ZEK1

NP_571170.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131095.1 → NP_571170.1 ephrin type-A receptor 3 precursor

See identical proteins and their annotated locations for NP_571170.1

Status: PROVISIONAL

Source sequence(s)

U89295

UniProtKB/Swiss-Prot

O13146

Related

ENSDARP00000096552.3, ENSDART00000105774.5

Conserved Domains (8) summary

cd09488
Location:911 → 971

SAM_EPH-R; SAM domain of EPH family of tyrosine kinase receptors

smart00454
Location:912 → 974

SAM; Sterile alpha motif

cd00063
Location:426 → 530

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:621 → 887

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:330 → 427

fn3; Fibronectin type III domain

pfam01404
Location:30 → 204

Ephrin_lbd; Ephrin receptor ligand binding domain

pfam07714
Location:626 → 883

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:550 → 621

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain