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Utp18 UTP18 small subunit processome component [ Rattus norvegicus (Norway rat) ]

Gene ID: 303456, updated on 17-Aug-2024

Summary

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Official Symbol
Utp18provided by RGD
Official Full Name
UTP18 small subunit processome componentprovided by RGD
Primary source
RGD:1309957
See related
EnsemblRapid:ENSRNOG00000002644 AllianceGenome:RGD:1309957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wdr50; RGD1309957
Summary
Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human UTP18 (UTP18 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 118.6), Thymus (RPKM 100.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Utp18 in Genome Data Viewer
Location:
10q26
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (79308785..79336241, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (78811879..78839338, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (81560929..81588156, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene thymosin, beta 10 like 2 Neighboring gene uncharacterized LOC120095281 Neighboring gene mbt domain containing 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Yokoyama A, et al. Mol Cell Biol, 2004 Jul. PMID 15199122, Free PMC Article
  2. Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment. Lee NH, et al. Proc Natl Acad Sci U S A, 1995 Aug 29. PMID 7667285, Free PMC Article
  3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U3 small nucleolar RNA-associated protein 18 homolog
Names
UTP18 small subunit (SSU) processome component
UTP18, small subunit (SSU) processome component, homolog
WD repeat domain 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135039.2 → NP_001128511.1  U3 small nucleolar RNA-associated protein 18 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZNH2
    Related
    ENSRNOP00000080215.1, ENSRNOT00000112449.2
    Conserved Domains (2) summary
    COG2319
    Location:211 → 541
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:244 → 284
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    79308785..79336241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086056.1 → XP_038941984.1  U3 small nucleolar RNA-associated protein 18 homolog isoform X1

    UniProtKB/TrEMBL
    D3ZNH2
    Related
    ENSRNOP00000003582.9, ENSRNOT00000003582.9
    Conserved Domains (2) summary
    COG2319
    Location:211 → 541
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:244 → 284
    7WD40; WD40 repeat [structural motif]

  2. XM_063269108.1 → XP_063125178.1  U3 small nucleolar RNA-associated protein 18 homolog isoform X3

    UniProtKB/TrEMBL
    A6HI29

  3. XM_063269107.1 → XP_063125177.1  U3 small nucleolar RNA-associated protein 18 homolog isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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